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Current Environmental Health Reports, 2015 The exposome concept takes a holistic approach facilitated by new and emerging technologies to describe 'the totality of human environmental (i.e. non-genetic) exposures from conception onwards, complementing the genome'. It provides a framework to advance the environmental epidemiology field that has until now focused almost exclusively on single ...
Oliver Robinson, Martine Vrijheid
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International Journal of Environmental Research and Public Health, 2021 International audienceAsthma is a widespread respiratory disease caused by complex contribution from genetic, environmental and behavioral factors. For several decades, its sensitivity to environmental factors has been investigated in single exposure (or
Valérie SIROUX +2 more
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The Exposome: Molecules to Populations
Annual Review of Pharmacology and Toxicology, 2019 Derived from the term exposure, the exposome is an omic-scale characterization of the nongenetic drivers of health and disease. With the genome, it defines the phenome of an individual. The measurement of complex environmental factors that exert pressure on our health has not kept pace with genomics and historically has not provided a similar level of ...
Megan M Niedzwiecki +2 more
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Clinics in Chest Medicine, 2019
This article on exposome and asthma focuses on the interaction of patients and their environments in various parts of their growth, development, and stages of life. Indoor and outdoor environments play a role in pathogenesis via levels and duration of exposure, with genetic susceptibility as a crucial factor that alters the initiation and trajectory of
Ahila, Subramanian, Sumita B, Khatri
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This article on exposome and asthma focuses on the interaction of patients and their environments in various parts of their growth, development, and stages of life. Indoor and outdoor environments play a role in pathogenesis via levels and duration of exposure, with genetic susceptibility as a crucial factor that alters the initiation and trajectory of
Ahila, Subramanian, Sumita B, Khatri
openaire +2 more sources
The exposome in rheumatoid arthritis
Joint Bone Spine, 2022The exposome integrates the variety and accumulation of exposures (external and internal) to which an individual is submitted to from conception to death. Exposome may therefore be a useful tool for understanding the diversity of these factors and their role in the pathophysiology of rheumatoid arthritis (RA).
Jerome, Biton +5 more
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Exposomics: The Exposome in Early Life
2019Individuals are exposed to a wide range of environmental factors of different nature, social, physical, and chemical over their lifetime. The cumulative effect of these environmental stressors, their interaction with genetic factors and key susceptible developmental stages determines disease risks.
Léa Maitre, Martine Vrijheid
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The Exposome in Toxicologic Pathology
Toxicologic Pathology, 2020The “exposome” is an individual’s lifetime spectrum of chemical exposures beginning at conception. An exposome includes general external influences such as pollution and weather; external individual-specific factors (diet, infections, self-selected chemical intake); and internal individual-specific constituents (metabolic byproducts, microbiome ...
Brad Bolon, Wanda M. Haschek
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A focus on the neural exposome
Neuron, 2022Many neurological disorders have complex etiologies that include noninheritable factors, collectively called the neural exposome. The National Institute of Neurological Disorders and Stroke is developing a new office with goals to advance our understanding of the multiple causes of neurological illness and to enable the development of more effective ...
Amir P, Tamiz +3 more
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The Exposome and Cardiovascular Health
Canadian Journal of Cardiology, 2023The study of the interplay between social factors, environmental hazards, and health has garnered much attention in recent years. The term "exposome" was coined to describe the total impact of environmental exposures on an individual's health and well-being, serving as a complementary concept to the genome.
Issam Motairek +3 more
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