Results 121 to 130 of about 8,026,862 (350)

Heterogeneity in malaria exposure and vaccine response: implications for the interpretation of vaccine efficacy trials [PDF]

, 2010
Michael White, Jamie T. Griffin, Chris Drakeley, Azra C. Ghani   +3 more
openalex   +1 more source

Association between Organophosphate Pesticide Exposure and Insulin Resistance in Pesticide Sprayers and Nonfarmworkers [PDF]

, 2020
Mathuramat Seesen, Roberto G. Lucchini, Somkiat Siriruttanapruk, Ratana Sapbamrer, Surat Hongsibsong, Susan Woskie, Pornpimol Kongtip   +6 more
openalex   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Cigarette smoking alters intestinal barrier function and Peyer's Patch composition [PDF]

, 2011
Smokers have a two-fold increased risk to develop Crohn’s disease (CD). However, little is known about the mechanisms through which smoking affects CD pathogenesis. Interestingly, the Peyer’s patches in the terminal ileum are the sites where the first CD
Bracke, Ken, Brusselle, Guy, Cuvelier, Claude, Demoor, Tine, Lambrecht, Bart, Plantinga, Maud, VERSCHUERE, Stephanie   +6 more
core  

LPG stove and fuel intervention among pregnant women reduce fine particle air pollution exposures in three countries: Pilot results from the HAPIN trial

, 2021
Jiawen Liao, Miles A. Kirby, Ajay Pillarisetti, Ricardo Piedrahita, Kalpana Balakrishnan, Sankar Sambandam, Krishnendu Mukhopadhyay, Wenlu Ye, Ghislaine Rosa, Fiona Majorin, Ephrem Dusabimana, Florien Ndagijimana, John P. McCracken, Erick Mollinedo, Oscar de León, Anaité Díaz-Artiga, Lisa M. Thompson, Katherine Kearns, Luke P. Naeher, Joshua P. Rosenthal, Maggie L. Clark, Kyle Steenland, Lance A. Waller, William Checkley, Jennifer L. Peel, Thomas Clasen, Michael Johnson, Vigneswari Aravindalochanan, Gloriose Bankundiye, Dana Boyd Barr, Alejandra Bussalleu, Eduardo Canúz, Adly Castañaza, Yunyun Chen, Marilú Chiang, Rachel Craik, Víctor G. Dávila‐Román, Lisa de las Fuentes, Lisa Elon, Juan Gabriel Espinoza, Sarada S. Garg, Sarah Hamid, Stella M. Hartinger, Steven A. Harvey, Mayarí Hengstermann, Ian Hennessee, Phabiola Herrera, Shakir Hossen, Penelope P. Howards, Lindsay M. Jaacks, Shirin Jabbarzadeh, Pattie Lenzen, Amy E. Lovvorn, Jane Mbabazi, Eric D. McCollum, Rachel Meyers, Lawrence H. Moulton, Alexie Mukeshimana, Bernard Mutariyani, Durairaj Natesan, Azhar Nizam, Jean de Dieu Ntivuguruzwa, Aris T. Papageorghiou, Naveen Puttaswamy, Elisa Puzzolo, Ashlinn Quinn, Karthikeyan Dharmapuri Rajamani, Usha Ramakrishnan, Rengaraj Ramasami, Alexander Ramirez, P. Barry Ryan, Sudhakar Saidam, Jeremy A. Sarnat, Suzanne Simkovich, Sheela Sinharoy, Kirk R. Smith, Damien Swearing, Gurusamy Thangavel, Ashley Toenjes, Viviane Valdes, Kendra N. Williams, Wenlu Ye, Bonnie N. Young   +82 more
openalex   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Mechanical Properties of Nano SiO2 and Carbon Fiber Reinforced Concrete after Exposure to High Temperatures [PDF]

, 2019
Linsong Wu, Zhenhui Lu, Chenglong Zhuang, Yu Chen, Ruihua Hu   +4 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source