Results 71 to 80 of about 4,380,023 (312)

Environmental Exposure, Biomonitoring and Exposure Assessment

Environmental exposure plays an important role in the development of diseases. However, individuals are exposed to complex mixtures of substances (e.g., chemicals, pollution, and diet) that change throughout a person’s life.

core   +1 more source

Sex differences in noradrenergic regulation of the medial prefrontal cortex in mice

Biology of Sex Differences
Background Norepinephrine (noradrenaline; NE) is a stress signal released from the locus coeruleus (LC) into the prefrontal cortex (PFC) to govern arousal, attention, and cognition.
Marcis V. Scroger, Alexandria C. Athanason, Noah M. Paperny, Andrea Liss, Katie T. Vo, Misha Muneeb, Mahum T. Siddiqi, Molly R. Batchelder, Iman Shahbaz, Serena Chan, Molly M. Deak, Anushree N. Karkhanis, Florence P. Varodayan   +12 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mapping efforts to identify populations at higher risk of lead exposure: HUD perspective [PDF]

HUD-mapping-efforts-populations-high-risk-lead-exposure-Dec-LEPAC-508 ...

core  

Ethnic differences in patterns of occupational exposure in New Zealand.

, 2011
OBJECTIVES: To investigate the differences in occupational exposure between Māori (New Zealand's indigenous people) and non-Māori. METHODS: Participants were randomly selected from the Electoral Roll.
Andrea 't Mannetje, Ellison-Loschmann, Lis, Pearce, Neil, 't Mannetje, Andrea, Eng, Amanda, Amanda Eng, Lis Ellison-Loschmann, Dave McLean, McLean, Dave, Cheng, Soo, Soo Cheng, Neil Pearce   +11 more
core   +1 more source

Gender differences in occupational exposure patterns [PDF]

, 2011
Objectives: The authors conducted a population-based survey to examine gender differences in occupational exposure patterns and to investigate whether any observed differences are due to: (a) gender differences in occupational distribution; and/or (b)
Ellison-Loschmann, Lis, L. Ellison-Loschmann, Pearce, Neil, Eng, Amanda, S. Cheng, A. Eng, Cheng, S, Pearce, N, Cheng, Soo, N. Pearce, McLean, D, Eng, A, D. McLean, 't Mannetje, Andrea, Ellison-Loschmann, L, A. 't Mannetje, McLean, Dave, t'Mannetje, A   +17 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Lead Exposure and Prevention Advisory Committee (LEPAC) : 2020 annual report to U.S. Department of Health and Human Services [PDF]

The objective of the Lead Exposure and Prevention Advisory Committee (LEPAC) is to review research andFederal programs and services related to lead poisoning and to identify effective services and best practices for addressing and preventing lead ...

core  

ExO: An Ontology for Exposure Science

, 2011
An ontology is a formal representation of knowledge within a domain and typically consists of classes, the properties of those classes, and the relationships between them.
Carolyn Mattingly, Judith Blake, Judith Blake, Carolyn J. Mattingly, Elaine A. Cohen Hubal, Elaine Cohen Hubal, Thomas E. McKone, Michael Callahan, Thomas McKone   +8 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source