Results 41 to 50 of about 850,044 (263)

Clarification of some aspects related to genotoxicity assessment

EFSA Journal, 2017
The European Commission requested EFSA to provide advice on the following: (1) the suitability of the unscheduled DNA synthesis (UDS) in vivo assay to follow‐up positive results in in vitro gene mutation tests; (2) the adequacy to demonstrate target ...
EFSA Scientific Committee, Anthony Hardy, Diane Benford, Thorhallur Halldorsson, Michael Jeger, Helle Katrine Knutsen, Simon More, Hanspeter Naegeli, Hubert Noteborn, Colin Ockleford, Antonia Ricci, Guido Rychen, Vittorio Silano, Roland Solecki, Dominique Turck, Maged Younes, Gabriele Aquilina, Riccardo Crebelli, Rainer Gürtler, Karen Ildico Hirsch‐Ernst, Pasquale Mosesso, Elsa Nielsen, Jan van Benthem, Maria Carfì, Nikolaos Georgiadis, Daniela Maurici, Juan Parra Morte, Josef Schlatter   +27 more
doaj   +1 more source

Short-term cold exposure supports human Treg induction in vivo

Molecular Metabolism, 2019
Objective: Obesity and type-2 diabetes (T2D) are metabolic diseases that represent a critical health problem worldwide. Metabolic disease is differentially associated with fat distribution, while visceral white adipose tissue (VAT) is particularly prone ...
Maike Becker, Isabelle Serr, Victoria K. Salb, Verena B. Ott, Laura Mengel, Matthias Blüher, Benno Weigmann, Hans Hauner, Matthias H. Tschöp, Carolin Daniel   +9 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Crystal Engineering as an Efficient Medicinal Chemistry Tool for Animal PK Bioavailability Enhancement in Early Pre-Clinical Research

Pharmaceuticals
Background: A lean crystal engineering study was performed on the early pre-clinical POLθ inhibitor MSC178 to enable sufficient exposure for high-dose PK studies.
Axel Becker, Carolina von Essen, Lars Burgdorf, Marc Lecomte, Daniel Bischof   +4 more
doaj   +1 more source

Vasomotor function in rat arteries after ex vivo and intragastric exposure to food-grade titanium dioxide and vegetable carbon particles

Particle and Fibre Toxicology, 2018
Background Humans are continuously exposed to particles in the gastrointestinal tract. Exposure may occur directly through ingestion of particles via food or indirectly by removal of inhaled material from the airways by the mucociliary clearance system ...
Ditte Marie Jensen, Daniel Vest Christophersen, Majid Sheykhzade, Gry Freja Skovsted, Jens Lykkesfeldt, Rasmus Münter, Martin Roursgaard, Steffen Loft, Peter Møller   +8 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Exploring exposure in vivo in chronic pain [PDF]

, 2021
In chronic pain patients, pain related fear considerably contributes to the maintenance of the experienced functional limitations. Pain related fear is fear of moving and/or fear of (renewed) injury, or fear of pain or other types of physical sensations, or fear of the future (for example of becoming restrained to a wheelchair, not being able to work ...
openaire   +1 more source

Biodistribution Survey of Oxidized Single-Wall Carbon Nanohorns Following Different Administration Routes by Using Label-Free Multispectral Optoacoustic Tomography

International Journal of Nanomedicine, 2019
Yujie Shi,1,* Dong Peng,2,* Dan Wang,1 Zongmin Zhao,3 Binlong Chen,1 Bing He,1 Yukun Zhu,2 Kun Wang,2 Jie Tian,2 Qiang Zhang1 1Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking ...
Shi Y, Peng D, Wang D, Zhao Z, Chen B, He B, Zhu Y, Wang K, Tian J, Zhang Q   +9 more
doaj  

Predicting the in vivo pulmonary toxicity induced by acute exposure to poorly soluble nanomaterials by using advanced in vitro methods

Particle and Fibre Toxicology, 2018
Background Animal models remain at that time a reference tool to predict potential pulmonary adverse effects of nanomaterials in humans. However, in a context of reduction of the number of animals used in experimentation, there is a need for reliable ...
Thomas Loret, Françoise Rogerieux, Bénédicte Trouiller, Anne Braun, Christophe Egles, Ghislaine Lacroix   +5 more
doaj   +1 more source