Results 61 to 70 of about 850,044 (263)

Subacute acrolein exposure to rat larynx in vivo

The Laryngoscope, 2018
Objectives/HypothesisInhaled pollutants can contact vocal fold tissue and induce detrimental voice changes. Acrolein is a pollutant in cigarette smoke and can also be inhaled during the combustion of fossil fuels, animal fats, and plastics in the environment.
Xinxin, Liu, Abigail C, Durkes, William, Schrock, Wei, Zheng, M Preeti, Sivasankar   +4 more
openaire   +3 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Virtual Reality Treatment in Acrophobia: A Comparison with Exposure in Vivo

CyberPsychology & Behavior, 2001
The aim of the present study was to evaluate the effectiveness of low-budget virtual reality exposure versus exposure in vivo in a within-group design in 10 individuals suffering from acrophobia. Virtual reality exposure was found to be at least as effective as exposure in vivo on anxiety and avoidance as measured with the Acrophobia Questionnaire (AQ),
Emmelkamp, P.M.G. (author), Bruynzeel, M. (author), Drost, L. (author), Van der Mast, C.A.P.G. (author)   +3 more
openaire   +6 more sources

Histomorphometric Evaluation of Subchronic and Chronic Effects of Novel Experimental Calcium Aluminate- and Calcium Silicate-Based Dental Cement Materials on Rat Liver, Kidney, Brain, and Spleen Tissues

Journal of Functional Biomaterials
Although biocompatible calcium silicate cements (CSCs) and calcium aluminate cements (CACs) may induce local and systemic adverse effects. This study aimed to evaluate the subchronic and chronic effects of experimental CAC and CSC mixtures on rat liver ...
Veljko Ilić, Sanja Milutinović-Smiljanić, Vladimir Biočanin, Jovana Kuzmanović Pfićer, Tatjana Tasić, Vesna Danilović, Nina Japundžić-Žigon, Smiljana Paraš, Vukoman Jokanović, Dejan Ćetković, Đorđe Antonijević   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The biology, function, and applications of exosomes as novel biomarkers for in-vivo drug exposure variability

Frontiers in Pharmacology
Exosomes have become one of the hotspots in life science research in recent years. As an important carrier of bio-information substances, they can mediate intercellular communication by carrying various bioactive substances, thereby activating specific ...
Yihui Yang, Yihui Yang, Zhujun Yu, Wei Dou, Wei Dou, Shuping Shi, Shuping Shi, Bo Zhang, Bo Zhang, Xin Liu, Xin Liu   +10 more
doaj   +1 more source

A complex proinflammatory cascade mediates the activation of HSCs upon LPS exposure in vivo. [PDF]

Blood Adv, 2022
Demel UM, Lutz R, Sujer S, Demerdash Y, Sood S, Grünschläger F, Kuck A, Werner P, Blaszkiewicz S, Uckelmann HJ, Haas S, Essers MAG.   +11 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Confounding Factors in the Transcriptome Analysis of an In-Vivo Exposure Experiment

PLOS ONE, 2016
In transcriptomics experimentation, confounding factors frequently exist alongside the intended experimental factors and can severely influence the outcome of a transcriptome analysis. Confounding factors are regularly discussed in methodological literature, but their actual, practical impact on the outcome and interpretation of transcriptomics ...
Bruning, O., Rodenburg, W., Wackers, P.F.K., van Oostrom, C., Jonker, M.J., Dekker, R.J., Rauwerda, H., Ensink, W.A., de Vries, A, Breit, T.M.   +9 more
openaire   +7 more sources