Results 151 to 160 of about 9,901,904 (299)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Lead Exposure and Prevention Advisory Committee (LEPAC) : 2022 annual report to U.S. Department of Health and Human Services [PDF]

The objective of the Lead Exposure and Prevention Advisory Committee (LEPAC) is to review research and federal programs and services related to lead poisoning and to identify effective services and best practices for addressing and preventing lead ...

core  

Discrepancy between Occupational Exposure Levels and Health Risks Limits the Health Benefits of a Concentration-Oriented VOC Regulation Strategy. [PDF]

ACS Environ Au
Wang D, Zhao J, Zhang X, Zhang Z, Zhang R, Zhang W, Zhao W, Shao X, Nie L.   +8 more
europepmc   +1 more source

Using Urinary Biomarkers to Estimate the Benzene Exposure Levels in Individuals Exposed to Benzene. [PDF]

Toxics, 2022
Cui S, Pang B, Yan H, Wu B, Li M, Xing C, Li J.   +6 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Descriptive analysis of exposure levels of organophosphate esters among firefighters, paramedics, and office workers. [PDF]

Ann Work Expo Health
Kooshki F, Zhang Y, Okeme JO, Rajaram N, Vermeulen R, Diamond ML, Demers PA, Arrandale VH.   +7 more
europepmc   +1 more source

Biological Responses of Pacific Herring Embryos to Crude Oil Are Quantifiable at Exposure Levels Below Conventional Limits of Quantitation for PAHs in Water and Tissues. [PDF]

Environ Sci Technol, 2023
Incardona JP, Linbo TL, Cameron JR, French BL, Bolton JL, Gregg JL, Donald CE, Hershberger PK, Scholz NL.   +8 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Assessment of particulate matter exposure levels and associated respiratory symptoms among oil seed processing factories workers. [PDF]

Sci Rep
Ayano B, Mekonen S, Dadi D.
europepmc   +1 more source

Assessment of EMF Human Exposure Levels Due to Wearable Antennas at 5G Frequency Band. [PDF]

Sensors (Basel), 2022
Gallucci S, Bonato M, Benini M, Chiaramello E, Fiocchi S, Tognola G, Parazzini M.   +6 more
europepmc   +1 more source