Results 91 to 100 of about 91,875,832 (294)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Occupational exposure to biological agents in the maintenance of sanitation infrastructures [PDF]

, 2017
The maintenance and cleaning of sanitation infrastructures are characterised by workers’ exposure to potentially hazardous biological agents. Thus, the aim of this study was to evaluate workers' occupational exposure to total mesophilic microorganisms ...
Rebelo, Andreia, Baptista, João, Silva, Bibiana, Santos, Joana, Oliveira, Rui   +4 more
core   +1 more source

Health hazard allowance for Nursing professionals: A reflective analysis under the principle of human dignity

Revista Latino-Americana de Enfermagem
Objective: to discuss the classification of the health hazard allowance due to exposure to biological agents attributed to Nursing professionals, based on legal and occupational parameters supported on the principle of human dignity. Method: an original
Rita de Cassia Ezaias, Maria Helena Palucci Marziale, Jair Aparecido Cardoso   +2 more
doaj   +3 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Division of Select Agents & Toxins : protecting America from dangerous [PDF]

Responsible for regulating the possession, use, and transfer of select agents and the importation of infectious biological agents into the U.S. that could cause disease in humans.CS256096GPublication date from document properties.infographic_dsat.pdfCDC ...

core  

Biological Consequences of Exposure to Mechanical Vibration

, 2018
A special issue of the journal Dose-Response entitled “Biological Consequences of Exposure to Mechanical Vibration” is proposed. When there is the interaction of physical agents, such as mechanical vibration to a body, physiological stress can be ...
Mario Bernardo-Filho, Redha Taiar, Christina Stark, Debra Bemben   +3 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Medidas de biossegurança em audiologia Biosafety precautions in audiology

Revista CEFAC, 2008
TEMA: Biossegurança na atuação audiológica. OBJETIVO: rever as medidas de precaução-padrão na literatura para o controle de infecção na audiologia.
Patrícia Cotta Mancini, Letícia Caldas Teixeira, Luciana Macedo de Resende, Adriana Martins Gomes, Laélia Cristina Caseiro Vicente, Patrícia Marques de Oliveira   +5 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source