Results 91 to 100 of about 422,721 (317)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Differences of occupational biohazard protection in relation to preventive system chosen by the company [PDF]

, 2015
El objetivo de este trabajo ha sido obtener información sobre el nivel de exposición y protección de los trabajadores a los agentes biológicos laborales en diferentes sectores de actividad valorando sus diferencias en relación al sistema preventivo ...
Aguilar Elena, Raúl, Martínez Merino, Víctor, Campo Barrio, Alberto, Morchón García, Rodrigo   +3 more
core  

Microbial Growth on Dust-Loaded Filtering Materials Used for the Protection of Respiratory Tract as a Factor Affecting Filtration Efficiency [PDF]

, 2018
This work aims at understanding the effects of various dust-loading conditions and the type of nonwovens used in the construction of FFRs on the safe use of those protective devices in situations of exposure to biological agents.
Justyna Szulc, Anita Jachowicz, Katarzyna Majchrzycka, Małgorzata Okrasa, Beata Gutarowska   +4 more
core   +1 more source

Review on standardized assessment and monitoring of the biosafety and biosecurity in laboratories

One Health & Risk Management, 2023
Introduction. Biological risks continue to intensify due to globalization and the ongoing emergence and re-emergence of communicable diseases. These factors are among the primary destabilizing elements of biological security and remain a major concern ...
Irina LOZNEANU
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Healthy and sustainable spaces, biosafety and wastes [PDF]

Revista Brasileira em Promoção da Saúde, 2011
Objective: To address the factors needed to develop an action plan towards building healthy public policy within the housing. Data Synthesis: As applied method, we combine concept and practice of healthy housing and other related concepts such as ...
Simone Cynamon Cohen, Débora Cynamon Kligerman, Mara Rejane Barroso Barcelos   +2 more
doaj  

BIOSSEGURANÇA E ACIDENTES DE TRABALHO COM PÉRFURO-CORTANTES ENTRE OS PROFISSIONAIS DE ENFERMAGEM DE HOSPITAL UNIVERSITÁRIO DE FORTALEZA–CE

Cogitare Enfermagem, 2008
Pesquisa documental exploratória, realizada em hospital público de Fortaleza em 2005. Objetivos: caracterizar os acidentes de trabalho ocorridos entre profissionais de saúde; analisar a freqüência com que ocorrem acidentes de trabalho com dispositivos ...
Débora Conceição Rodrigues Paulino, Marcos Venícios Oliveira Lopes, Isaura Letícia Tavares Palmeira Rolim   +2 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Strategies and Methods for Investigation of Airborne Biological Agents From Work Environments in Germany [PDF]

, 2007
In 2004/2005, a European Twinning Project was carried out to support Polish occupational safety and health institutions in putting into practice Directive 2000/54/EC regarding the protection of workers from risks related to exposure to biological agents ...
Kiel, K., Kolk, A., Albrecht, A.
core