Results 101 to 110 of about 91,875,832 (294)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

The biological agents in the working environment [PDF]

, 2005
W artykule przedstawiono nowe obowiązujące rozporządzenie ministra zdrowia wdrażające do prawa polskiego postanowienia Dyrektywy 2000/54/WE w sprawie ochrony pracowników przed ryzykiem związanym z narażeniem na działanie czynników biologicznych w miejscu
Zapór, L.
core  

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Evaluation of Soldiers’ Knowledge and Sense of Threats Regarding Exposure to Biological Risk Factors at the Place of Service

Exposure to harmful biological agents and the level of knowledge about specific risk factors are extremely important topics, especially among military personnel.
Aleksandra Lis, Paweł Szymański, Magdalena Zawadzka, Justyna Marszałkowska-Jakubik   +3 more
core   +1 more source

Chi-square automatic interaction detection (CHAID) analysis of the use of safety goggles and face masks as personal protective equipment (PPE) to protect against occupational biohazards

Journal of Biosafety and Biosecurity
Background: This study represents the first Spanish investigation to rigorously evaluate compliance with the use of safety goggles and face masks as essential personal protective equipment (PPE) in companies with workplaces involving exposure to ...
Raúl Aguilar-Elena, Juán José Agún-González   +1 more
doaj   +1 more source

Accidents cutting and piercing in a School of Dentistry [PDF]

RGO: Revista Gaúcha de Odontologia, 2010
Objective: To assess the occurrence and characteristics of the reported accidents with perforating-cutting materials involving students, staff and faculty members, between 2000 and 2005 at the Dental Clinic of the School of Dentistry of the University of
Maria Cristina Zindel Deboni, Maria da Graça Naclério-Homem, Andreia Aparecida Traina, Mariana Aparecida Brozoski   +3 more
doaj  

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Environmental and occupational exposure assessment

, 2017
Introduction: Environmental and Occupational Exposure Assessment: a) Indoor Environmental Quality (Office buildings, schools, waiting rooms – tasks developed do not involve/ required manipulation of chemical or biological agents, nor exposure to physical
Nogueira, Ana, Cano, Manuela
core  

Exposure to biological agents: a case study in portuguese buses [PDF]

, 2018
Buses are used by thousands of people in all cities. Passengers are faced with a microenvironment, which may have an impact on their human health. The present study aimed at evaluating and analysing of exposure to biological agents in collective road ...
Santos, Joana
core   +1 more source