Results 51 to 60 of about 8,188,103 (287)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

RNA-seq transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis [PDF]

, 2014
Bovine tuberculosis, caused by infection with Mycobacterium bovis, is a major endemic disease affecting cattle populations worldwide, despite the implementation of stringent surveillance and control programs in many countries.
Browne, JA, Gordon, SV, Gormley, E, Hokamp, K, Killick, KE, MacHugh, DE, Magee, DA, McLoughlin, KE, Meade, KG, Nalpas, NC, O'Farrelly, C, Park, SD, Rue-Albrecht, K   +12 more
core   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Genome-Wide Identification and Analysis of the WRKY Gene Family in the Xerophytic Evergreen Ammopiptanthus nanus

Agronomy, 2020
The WRKY family of transcription factors plays important roles in plant growth and responses to biotic and abiotic stresses. Ammopiptanthus nanus, the only evergreen broadleaf shrub endemic to the desert and semi-desert regions of northwestern China, is ...
Xin Hao, Shuyao Wang, Yingying Chen, Yue Qu, Hongjun Yao, Yingbai Shen   +5 more
doaj   +1 more source

Genome-Wide Identification and Analysis of the Ascorbate Peroxidase (APX) Gene Family of Winter Rapeseed (Brassica rapa L.) Under Abiotic Stress

Frontiers in Genetics, 2022
Winter Brassica rapa (B. rapa) is an important oilseed crop in northern China, but the mechanism of its cold resistance remains unclear. Ascorbate peroxidase (APX) plays important roles in the response of this plant to abiotic stress and in scavenging ...
Li Ma, Weiliang Qi, Jing Bai, Haiyun Li, Yan Fang, Jia Xu, Yaozhao Xu, Xiucun Zeng, Yuanyuan Pu, Wangtian Wang, Lijun Liu, Xuecai Li, Wancang Sun, Junyan Wu   +13 more
doaj   +1 more source

In vivo imaging of the tonoplast intrinsic protein family in Arabidopsis roots [PDF]

, 2009
Background: Tonoplast intrinsic proteins (TIPs) are widely used as markers for vacuolar compartments in higher plants. Ten TIP isoforms are encoded by the Arabidopsis genome.
Frigerio, Lorenzo, Gattolin, Stefano, Hunter, P. R. (Paul R.), Khonsari, Roman H., Sorieul, Mathias   +4 more
core   +4 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Genome-Wide Analysis of the Histone Modification Gene (HM) Family and Expression Investigation during Anther Development in Rice (Oryza sativa L.)

Plants
Histone modification plays a crucial role in chromatin remodeling and regulating gene expression, and participates in various biological processes, including plant development and responses to stress. Several gene families related to histone modification
Yongxiang Huang, Jiawei Liu, Long Cheng, Duo Xu, Sijia Liu, Hanqiao Hu, Yu Ling, Rongchao Yang, Yueqin Zhang   +8 more
doaj   +1 more source

TALE Transcription Factors in Sweet Orange (Citrus sinensis): Genome-Wide Identification, Characterization, and Expression in Response to Biotic and Abiotic Stresses

Frontiers in Plant Science, 2022
Three-amino-acid-loop-extension (TALE) transcription factors comprise one of the largest gene families in plants, in which they contribute to regulation of a wide variety of biological processes, including plant growth and development, as well as ...
Weiye Peng, Weiye Peng, Yang Yang, Yang Yang, Jing Xu, Jing Xu, Erping Peng, Erping Peng, Suming Dai, Suming Dai, Liangying Dai, Liangying Dai, Yunsheng Wang, Yunsheng Wang, Tuyong Yi, Tuyong Yi, Bing Wang, Bing Wang, Dazhi Li, Dazhi Li, Na Song, Na Song   +21 more
doaj   +1 more source

Attention modulates the processing of emotional expression triggered by foveal faces [PDF]

, 2006
To investigate whether the processing of emotional expression for faces presented within foveal vision is modulated by spatial attention, event-related potentials (ERPs) were recorded in response to stimulus arrays containing one fearful or neutral face ...
Eimer, Martin, Holmes, A., Kiss, Monika
core   +1 more source