Results 131 to 140 of about 1,642,960 (338)

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Routes for breaching and protecting genetic privacy

, 2013
We are entering the era of ubiquitous genetic information for research, clinical care, and personal curiosity. Sharing these datasets is vital for rapid progress in understanding the genetic basis of human diseases.
A Acquisti, A Cavoukian, A Kong, A Machanavajjhala, A Narayanan, AD Johnson, AJ Pakstis, AK Manning, AL McGuire, Arvind Narayanan, B Fons, B Malin, B Malin, BA Malin, BM Henn, C Dwork, C Shannon, CD Huff, D Clayton, D He, D Zubakov, DJ Solve, DR Nyholt, DW Craig, EA Zerhouni, EE Schadt, EM Ramos, F Liu, G Church, H Lango Allen, H Li, HK Im, HS Venter, J Burn, J Gitschier, J Kaiser, J Kaye, J Kaye, J Lee, J Marchini, JE Lunshof, JH Park, JM Oliver, JP Roberts, K Benitez, K El Emam, K El Emam, K Silventoinen, KA Tryka, KB Jacobs, KS Kendler, L Kamm, L Sweeney, L Sweeney, LA Sweeney, LA Sweeney, LAP Kohn, LL Rodriguez, M Canim, M Gymrek, M Gymrek, M Kantarcioglu, M Kayser, MD Mailman, N Chatterjee, N Homer, NN Taleb, P Bohannon, P Kwok, P Ohm, P Paillier, PM Visscher, R Braun, R Drmanac, R Khan, R Noumeir, RL Bennett, S Byers, S McClure, S Sankararaman, S Walsh, SE Brenner, SF Terry, SH Friend, T Lumley, TE King, TE King, V Bafna, W Fu, W Hartzog, WG Hill, WW Lowrance, XL Ou, Yaniv Erlich, Z Lin   +94 more
core   +1 more source

Computing edge version of metric dimension of certain chemical networks

Scientific Reports
In the modern digital sphere, graph theory is a significant field of research that has a great deal of significance. It finds widespread application in computer science, robotic directions, and chemistry.
Muhammad Umer Farooq, Muhammad Hussain, Ahmed Zubair Jan, Afraz Hussain Mjaeed, Mirwais Sediqma, Ayesha Amjad   +5 more
doaj   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Using MaxMSP to Integrate Learning of Physics and Music [PDF]

, 2015
poster abstractThis project integrates musical activity with the learning of concepts in areas such as physics and computer science. While the expression of musical ideas utilizes the laws of physics on many levels, the study of the two fields often is ...
Deal, Scott, Tyson II, Alan B.
core  

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Performance analysis of a MIMO Optical wireless link with space Time Block Code (STBC) [PDF]

This thesis report is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Computer Science and Engineering, 2010.Cataloged from PDF version of thesis report.Includes bibliographical references (page 22 ...
Islam, Md. Zahirul
core  

METABOLÔMICA DE PLANTAS: MÉTODOS E DESAFIOS

Química Nova
Metabolomics has played a central role in various areas of plant sciences, offering new perspectives for the advancement of agriculture, drug discovery, chemical ecology and taxonomy.
Alan C. Pilon, Denise M. Selegato, Richard P. Fernandes, Paula C. P. Bueno, Danielle R. Pinho, Fausto Carnevale Neto, Rafael T. Freire, Ian Castro-Gamboa, Vanderlan S. Bolzani, Norberto P. Lopes   +9 more
doaj   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source