Results 111 to 120 of about 234,285 (301)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

3D FACIAL LANDMARK-BASED DECEPTION DETECTION IN VIDEO USING GRU MODEL

Mağallaẗ Al-kūfaẗ Al-handasiyyaẗ
Deception detection is an interdisciplinary field that has researchers from psychology, criminology, and computer science. We propose the automated detection of deception based on facial micro expressions which occur spontaneously in response to the ...
Amira Himyari, Israa Hadi
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Bioinformatics: an overview for cancer research

, 2012
Bioinformatics is a new science that is glowing out in the recent years. It is a multidisciplinary science that is made out of different kinds of other scientific fields like biology, computer science, chemistry, statistics, mathematics and others.
Lu, Joan, Al-Rajab, Murad
core  

Architectural support for Global Smart Spaces

, 2002
This work was supported by EPSRC grant GR/M78403/GR/M76225, “Supporting Internet Computation in Arbitrary Geographical Locations”.A GLObal Smart Space (GLOSS) provides support for interaction amongst people, artefacts and places while taking account of ...
Wilson, Andy, Richard Connor, Dearle, A, Graham Kirby, McCarthy, Andrew John, Kevin Mullen, Mullen, Kevin, Yang, Yanyan, Mullen, Kevin Matthew, Andy Wilson, Connor, Richard, Ron Morrison, Paula Welen, Kirby, G, Welen, Paula, Andrew McCarthy, Morrison, R, Morrison, Ron, Yanyan Yang, Yang, Yang, Connor, R, McCarthy, Andrew, Dearle, Alan, Kirby, Graham, Alan Dearle, Welen, P, Wilson, A   +26 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Extracting insights from the shape of complex data using topology

, 2013
This paper applies topological methods to study complex high dimensional data sets by extracting shapes (patterns) and obtaining insights about them. Our method combines the best features of existing standard methodologies such as principal component and
Carlsson, J, Lum, P. Y., Carlsson, G, Vejdemo Johansson, Mikael Vilhelm, Carlsson, G., Alagappan, M., Vejdemo-Johansson, Mikael, Carlsson, J., Singh, G, Lehman, A., Lehman, A, Alagappan, M, Vejdemo-Johansson, Mikael,, Ishkanov, T, Singh, G., Ishkanov, T., Lum, P Y   +16 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source