Results 131 to 140 of about 30,376,400 (291)

Prognostic value of microRNAs in colorectal cancer: a meta-analysis

Cancer Management and Research, 2018
Song Gao,1,* Zhi-Ying Zhao,2,* Rong Wu,1 Yue Zhang,3 Zhen-Yong Zhang1 1Second Department of Clinical Oncology, Shengjing Hospital of China Medical University, 2School of Computer Science and Engineering, Northeastern University, Shenyang, 3First Clinical
Gao S, Zhao ZY, Wu R, Zhang Y, Zhang ZY
doaj  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Computer Science Concepts - Introduction

, 2010
This lecture forms part of the "Introduction" topic of the Computer Science Concepts module.
Rong Yang, UKOER, Open Educational Repository in Support of Computer Science   +2 more
core  

Chum salmon egg extracts induce upregulation of collagen type I and exert antioxidative effects on human dermal fibroblast cultures

Clinical Interventions in Aging, 2016
Atsushi Yoshino,1 Natalia Polouliakh,1–3 Akira Meguro,1 Masaki Takeuchi,1,4 Tatsukata Kawagoe,1 Nobuhisa Mizuki1 1Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, 2Sony ...
Yoshino A, Polouliakh N, Meguro A, Takeuchi M, Kawagoe T, Mizuki N   +5 more
doaj  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Computer Science Concepts - Prolog

, 2010
This lecture forms part of the "Prolog" topic of the Computer Science Concepts module.
Rong Yang, UKOER, Open Educational Repository in Support of Computer Science   +2 more
core  

Rethinking the production and publication of machine-readable expressions of research findings

Scientific Data
Scientific literature is the primary expression of scientific knowledge and an important source of research data. However, scientific knowledge expressed in narrative text documents is not inherently machine readable.
Markus Stocker, Lauren Snyder, Matthew Anfuso, Oliver Ludwig, Freya Thießen, Kheir Eddine Farfar, Muhammad Haris, Allard Oelen, Mohamad Yaser Jaradeh   +8 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Computer science reconsidered

Ubiquity, 2007
openaire   +2 more sources