Results 1 to 10 of about 4,059 (184)

Retrospective analysis of serum NELL-1 and EXT1/2: no significant predictive value for treatment response in a cohort of membranous nephropathy patients [PDF]

Renal Failure
Neural epidermal growth factor-like protein 1 (NELL-1) and the exostosin 1/2 complex (EXT1/2) are recently identified target antigens in membranous nephropathy (MN), yet their prevalence and clinical features in Chinese populations remain poorly ...
Yemei Dai, Rongrong Feng, Xiaowen Duan, Xiaole Su, Lihua Wang   +4 more
doaj   +4 more sources

Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans[S] [PDF]

Journal of Lipid Research, 2015
Elevated nonfasting TG-rich lipoprotein levels are a risk factor for CVD. To further evaluate the relevance of LDL-receptor (LDLr) pathway and heparan sulfate proteoglycans (HSPGs) in TG homeostasis, we analyzed fasting and postprandial TG levels in mice
Hans L. Mooij, Sophie J. Bernelot Moens, PhilipL.S.M. Gordts, KristinI. Stanford, ErinM. Foley, MarjoleinA.W. van den Boogert, JuliaJ. Witjes, H.Carlijne Hassing, MichaelW. Tanck, MichielA.J. van de Sande, J.Han Levels, JohnJ.P. Kastelein, ErikS.G. Stroes, GeesjeM. Dallinga-Thie, JeffD. Esko, Max Nieuwdorp   +15 more
doaj   +10 more sources

Fibroblast EXT1-levels influence tumor cell proliferation and migration in composite spheroids. [PDF]

PLoS ONE, 2012
BACKGROUND: Stromal fibroblasts are important determinants of tumor cell behavior. They act to condition the tumor microenvironment, influence tumor growth, support tumor angiogenesis and affect tumor metastasis.
Cecilia Österholm, Ning Lu, Åsa Lidén, Tine V Karlsen, Donald Gullberg, Rolf K Reed, Marion Kusche-Gullberg   +6 more
doaj   +8 more sources

Dual roles of exostosin glycosyltransferase 1 in Zika virus infection [PDF]

Virulence
Many factors involved in heparan sulfate (HS) biosynthesis and metabolism have been reported to play roles in viral infection. However, the detailed mechanisms are still not fully understood. In this study, we report that exostosin glycosyltransferase 1 (
Jiaxin Ling, Asifa Khan, Matthias Denkewitz, Marco Maccarana, Åke Lundkvist, Jin-Ping Li, Jinlin Li   +6 more
doaj   +2 more sources

Clinical significance of exostosin 1 in confirmed and suspected lupus membranous nephropathy [PDF]

Lupus Science and Medicine, 2023
Objective This study aimed to investigate the clinical significance of exostosin 1 (EXT1) in confirmed and suspected lupus membranous nephropathy (LMN).Methods EXT1 was detected in 67 renal tissues of M-type phospholipase A2 receptor (PLA2R)-negative and
Xiaohong Li, Tian ye, Mengya Jiang, Xueyan Zeng, Dan Zong, Yuanyuan Du, Biao Huang, Xuanli Tang   +7 more
doaj   +2 more sources

The identification of a novel frameshift insertion mutation in the EXT1 gene in a Chinese family with hereditary multiple exostoses [PDF]

Clinical Case Reports, 2022
To identify the pathogenic gene variation in a Chinese family with Hereditary Multiple Exostoses (HME). By examining blood‐sourced DNA and clinical manifestations of the proband and his family members, the whole exome sequencing (WES) and Sanger ...
Wanlu Liu, Xinwei Shi, Yuqi Li, Fuyuan Qiao, Yuanyuan Wu   +4 more
doaj   +2 more sources

Haploinsufficiency of EXT1 and Heparan Sulphate Deficiency Associated with Hereditary Multiple Exostoses in a Pakistani Family [PDF]

Medicina, 2022
Background and Objectives: Hereditary multiple exostoses (HME) is a disease characterized by cartilage-capped bony protuberances at the site of growth plates of long bones.
Muhammad Ajmal, Hafsah Muhammad, Muhammad Nasir, Muhammad Shoaib, Salman Akbar Malik, Irfan Ullah   +5 more
doaj   +2 more sources

Heparan Sulfate Biosynthesis Enzyme, Ext1, Contributes to Outflow Tract Development of Mouse Heart via Modulation of FGF Signaling. [PDF]

PLoS ONE, 2015
Glycosaminoglycans are important regulators of multiple signaling pathways. As a major constituent of the heart extracellular matrix, glycosaminoglycans are implicated in cardiac morphogenesis through interactions with different signaling morphogens ...
Rui Zhang, Peijuan Cao, Zhongzhou Yang, Zhenzhen Wang, Jiu-Lin Wu, Yan Chen, Yi Pan   +6 more
doaj   +3 more sources

Hereditary Multiple Osteochondromas and Acute Lymphoblastic Leukemia: A Possible Role for EXT1 and EXT2 in Hematopoietic Malignancies [PDF]

American Journal of Medical Genetics Part A, Volume 197, Issue 7, July 2025.
ABSTRACT Hereditary multiple osteochondromas (HMO) is an autosomal dominant disorder caused by heterozygous deleterious variants in the EXT1 or EXT2 genes. While the clinical core phenotype is well established and mainly consists of bone deformities, limb length discrepancies, multiple benign bone neoplasms, and increased risk of chondrosarcoma, the ...
Francesco Comisi, Carmela Fusco, Rosamaria Mura, Carla Cerruto, Leonardo D'Agruma, Salvatore Carnazzo, Marco Castori, Salvatore Savasta   +7 more
wiley   +2 more sources

4-HIAA Blocks Methamphetamine-Induced Conditioned Place Preference in Mice Through Modulation of the 5-HT Pathway in the Nucleus Accumbens. [PDF]

Addict Biol
4‐HIAA crosses the blood–brain barrier. Treatment (1‐mg/kg) inhibited CPP acquisition, promoted extinction and prevented relapse. These behavioural effects were associated with changes in nucleus accumbens 5‐HT expression. ABSTRACT 4‐hydroxyindole‐3‐acetic acid (4‐HIAA) is a metabolite of psilocin.
Wu Y, Ran J, Mo J, Wang J.
europepmc   +2 more sources