Results 1 to 10 of about 12,622 (181)

Structure of the human heparan sulfate polymerase complex EXT1-EXT2

Nature Communications, 2022
Heparan sulfates are long and complex polysaccharides that mediate a large number of biological processes at the cell surface. Here, the authors provide structural and functional insights into the human EXT1-EXT2 complex that carries out the ...
Francisco Leisico, Juneina Omeiri, Christine Le Narvor   +2 more
exaly   +6 more sources

Genotype and phenotype correlation analysis in 27 families with multiple osteochondroma and validation by ATDC5 chondrocyte models [PDF]

Bone & Joint Research
Aims: This study aimed to explore the genotype and phenotype correlation of patients with multiple osteochondroma (MO), and validate phenotypic differences in ATDC5 cell model with EXT1 or EXT2 gene disruption (EXT1 -/- or EXT2 -/-).
Xiaoyan Guo, Mingrui Lin, Shan Xu, Boling Liu, Rui Zhang, Shu Liu, Yuancheng Pan   +6 more
doaj   +2 more sources

4-HIAA Blocks Methamphetamine-Induced Conditioned Place Preference in Mice Through Modulation of the 5-HT Pathway in the Nucleus Accumbens. [PDF]

Addict Biol
4‐HIAA crosses the blood–brain barrier. Treatment (1‐mg/kg) inhibited CPP acquisition, promoted extinction and prevented relapse. These behavioural effects were associated with changes in nucleus accumbens 5‐HT expression. ABSTRACT 4‐hydroxyindole‐3‐acetic acid (4‐HIAA) is a metabolite of psilocin.
Wu Y, Ran J, Mo J, Wang J.
europepmc   +2 more sources

Long-term outcomes in primary membranous nephropathy: a Chinese cohort study with novel target antigen [PDF]

Frontiers in Immunology
BackgroundLong-term antigen-specific data in PMN among Chinese populations remain limited. This study evaluated six target antigens and their clinical significance during extended follow-up.MethodsWe retrospectively analyzed 132 treatment-naïve PMN ...
Ping Guo, Ping Guo, Wenli Li, Wenli Li, Shasha Chen, Xiangyu Yang, Xiangyu Yang, Lisha Ma, Lisha Ma, Changwei Wu, Guisen Li, Guisen Li, Wei Wang, Wei Wang   +13 more
doaj   +2 more sources

Glomerular Exostosin-Positivity is Associated With Disease Activity and Outcomes in Patients With Membranous Lupus Nephritis [PDF]

Kidney International Reports
Introduction: The relationship of exostosin 1 and exostosin 2 (EXT1/EXT2) expression and outcomes in membranous lupus nephritis (MLN) was controversial.
Xi Xia, Suchun Li, Zhipeng Wang, Siyang Ye, Yuting Fan, Wenxing Peng, Wenfang Chen, Fengxian Huang, Ruihan Tang, Wei Chen   +9 more
doaj   +2 more sources

Exostoisns (EXT1/2) in Head and Neck Cancers: An In Silico Analysis and Clinical Correlates [PDF]

International Dental Journal
Summary: Objectives: The exostosins (EXT), which are responsible for heparan sulfate backbone synthesis and play a vital role in tissue homeostasis, have been reported to be correlated with prognosis of various cancers.
Yiping Wang, Yan Huang, Houwei Zhu, Zhenzhen Guo, Jun Cheng, Churen Zhang, Ming Zhong   +6 more
doaj   +2 more sources

Cellular SLC35B4 promotes internalization during influenza A virus entry [PDF]

mBio
SLC35B4, a nucleotide sugar transporter that mediates the transport of UDP-GlcNAc and UDP-xylose, was found to be required for the replication of influenza A virus (IAV) of the H5N1 subtype in our genome-wide siRNA library screen. We found that defective
Guangwen Wang, Li Jiang, Ya Yan, Fandi Kong, Qibing Li, Jie Zhang, Shuangshuang Hou, Bo Wang, Xiurong Wang, Huihui Kong, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Hualan Chen, Chengjun Li   +15 more
doaj   +2 more sources

Cases report: Mosaic structural variants of the EXT1 gene in previously genetically unconfirmed multiple osteochondromas [PDF]

Frontiers in Genetics
Multiple osteochondromas (MO) is a rare autosomal dominant skeletal disorder characterized by the development of multiple benign tumors known as osteochondromas. The condition is predominantly caused by loss-of-function variants in the EXT1 or EXT2 genes,
Artem Borovikov, Andrey Marakhonov, Aysylu Murtazina, Kseniya Davydenko, Alexandra Filatova, Nailya Galeeva, Varvara Kadnikova, Natalya Ogorodova, Daria Gorodilova, Ilya Kanivets, Ilya Kanivets, Denis Pyankov, Konstantin Zherdev, Konstantin Zherdev, Aleksandr Petel’guzov, Pavel Zubkov, Alexander Polyakov, Olga Shchagina, Mikhail Skoblov   +18 more
doaj   +2 more sources

Surgical Approach and Considerations for Compressive Thoracic Intraspinal Osteochondroma in Familial Hereditary Multiple Exostosis [PDF]

Diseases
Introduction: Hereditary multiple exostosis or hereditary multiple osteochondromas is a very rare clinical condition. Usually, these lesions tend to occur in the pediatric population, remaining silent until adulthood.
Corneliu Toader, Antonio-Daniel Corlatescu, Nicolaie Dobrin, Razvan-Adrian Covache-Busuioc, Horia Petre Costin, Alexandru Vlad Ciurea   +5 more
doaj   +2 more sources

A novel mutation in ext2 caused hereditary multiple exostoses through reducing the synthesis of heparan sulfate [PDF]

Genetics and Molecular Biology, 2021
Hereditary multiple exostoses (HME) is a rare skeletal disorder characterized by the formation of multiple benign cartilage-capped tumors, usually in the metaphyseal region of the long bones.
Caixia Xian, Mingwei Zhu, Tianying Nong, Yiqiang Li, Xingmei Xie, Xia Li, Jiangui Li, Jingchun Li, Jianping Wu, Weizhe Shi, Ping Wei, Hongwen Xu, Ya-ping Tang   +12 more
doaj   +2 more sources