Results 21 to 30 of about 12,622 (181)
Possible effects of EXT2 on mesenchymal differentiation - lessons from the zebrafish [PDF]
Orphanet Journal of Rare Diseases, 2014 Mutations in the EXT genes disrupt polymerisation of heparan sulphates (HS) and lead to the development of osteochondroma, an isolated/sporadic- or a multifocal/hereditary cartilaginous bone tumour. Zebrafish (Danio rerio) is a very powerful animal model which has shown to present the same cartilage phenotype that is commonly seen in mice model and ...
Wiweger, M.I. +4 more
openaire +3 more sources
Cytoskeletal Abnormalities in Chondrocytes with EXT1 and EXT2 Mutations [PDF]
Journal of Bone and Mineral Research, 2000 Abstract The EXT genes are a group of putative tumor suppressor genes that previously have been shown to participate in the development of hereditary multiple exostoses (HME), HME-associated and isolated chondrosarcomas. Two HME disease genes, EXT1 and EXT2, have been identified and are expressed ubiquitously.
M A, Bernard +10 more
openaire +2 more sources
Heparanase and Syndecan-4 Are Involved in Low Molecular Weight Fucoidan-Induced Angiogenesis
Marine Drugs, 2015 Induction of angiogenesis is a potential treatment for chronic ischemia. Low molecular weight fucoidan (LMWF), the sulfated polysaccharide from brown seaweeds, has been shown to promote revascularization in a rat limb ischemia, increasing angiogenesis ...
Oualid Haddad +10 more
doaj +1 more source
Carriers of loss-of-function mutations in EXT display impaired pancreatic beta-cell reserve due to smaller pancreas volume. [PDF]
PLoS ONE, 2014 Exotosin (EXT) proteins are involved in the chain elongation step of heparan sulfate (HS) biosynthesis, which is intricately involved in organ development.
Sophie J Bernelot Moens +11 more
doaj +1 more source
Journal of Public Health in Africa, 2020 Recent genome-wide association studies and replication analyses have reported the association of variants of the exostosin- 2 gene (EXT2) and risk of type 2 diabetes (T2D) in some populations, but not in others.
Serge Y. Ouedraogo +13 more
doaj +1 more source
Journal of Nutrition and Metabolism, 2023 Background. Ashwagandha extracts play a significant role in traditional Indian medicine to help treat a wide range of disorders from amnesia, erectile dysfunction, neurodegenerative and cardiovascular diseases, cancer, stress, anxiety, and many more ...
Franco Cavaleri +4 more
doaj +1 more source
Gedanken experiments for the determination of two-dimensional linear second gradient elasticity coefficients [PDF]
, 2015 In the present paper, a two-dimensional solid consisting of a linear elastic isotropic material, for which the deformation energy depends on the second gradient of the displacement, is considered.
Andreaus, Ugo +3 more
core +1 more source
New Insights into Potocki-Shaffer Syndrome: Report of Two Novel Cases and Literature Review
Brain Sciences, 2020 Potocki-Shaffer syndrome (PSS) is a rare non-recurrent contiguous gene deletion syndrome involving chromosome 11p11.2. Current literature implies a minimal region with haploinsufficiency of three genes, ALX4 (parietal foramina), EXT2 (multiple exostoses),
Slavica Trajkova +7 more
doaj +1 more source
EXT2 (exostoses (multiple) 2) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on EXT2 (exostoses (multiple) 2), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire +2 more sources
Orthopaedic Surgery, 2020 Objective To find novel potential gene mutations other than EXT1 and EXT2 mutations, to expand the mutational spectrum of EXT and to explore the correlation between clinical outcome and genotype in patients with hereditary multiple exostoses (HME ...
Chao Liang +4 more
doaj +1 more source