Results 111 to 120 of about 690,349 (272)

Certain Extension of the Hurwitz-Lerch Zeta Function and its Properties

مجلّة جامعة عدن للعلوم الأساسيّة والتّطبيقيّة, 2020
The main object of this paper is to introduce a new extension of Hurwitz-Lerch Zeta function by using the extended Beta function given in [1]. Some recurrence relations, generating functions and integral representations are derived for that new extension.
Ahmed Ali Al-Gonah, Waleed Khadher Mohammed   +1 more
doaj  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Extension of the Beta function in several variables and applications for multivariate orthogonal polynomials

Journal of Inequalities and Applications
The fundamental aim of this article is to investigate an extension of the generalized Beta function introduced in (Chaudhry et al. in J. Comput. Appl. Math. 78(1):19–32, 1997) from two variables to three or more variables. The properties of such extended
Nawal Helal Al-harbi, Mustapha Raïssouli   +1 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

An Adaptive Multi-Bernoulli Filter for Coexisting Point Target and Extended Target Tracking With Unknown Detection Probability

IEEE Access
This paper proposes an adaptive multi-Bernoulli (MB) filter for coexisting point target and extended target tracking, where the detection probability of each target is unknown and time-varying. The detection probability of the target directly affects the
Yuansheng Li, Ling Cui, Junhu Ma, Zhaohui Luo   +3 more
doaj   +1 more source

Some Characterizations of the Extended Beta and Gamma Functions: Properties and Applications

International Journal of Material and Mathematical Sciences, 2021
The article represents the elementary and general introduction of some characterizations of the extended gamma and beta Functions and their important properties with various representations. This paper provides reviews of some of the new proposals to extend the form of basic functions and some closed-form representation of more integral functions is ...
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

\(L^p\)-approximation and generalized growth of generalized biaxially symmetric potentials on hyper sphere

Journal of Numerical Analysis and Approximation Theory, 2018
The generalized order of growth and generalized type of an entire function \(F^{\alpha,\beta}\) (generalized biaxisymmetric potentials) have been obtained in terms of the sequence \(E_n^p(F^{\alpha,\beta},\Sigma_r^{\alpha,\beta})\) of best real ...
Devendra Kumar
doaj   +2 more sources

A Wright-Based Generalization of the Euler Beta Function with Statistical Applications

Mathematics
In recent years, special function theory has played an increasingly important role in the development of advanced mathematical models and statistical distributions.
Layth T. Khudhuir, Hiba F. Al-Janaby, Firas Ghanim, Alina Alb Lupaș   +3 more
doaj   +1 more source