Results 91 to 100 of about 690,349 (272)

Extended Riemann-Liouville type fractional derivative operator with applications

Open Mathematics, 2017
The main purpose of this paper is to introduce a class of new extended forms of the beta function, Gauss hypergeometric function and Appell-Lauricella hypergeometric functions by means of the modified Bessel function of the third kind.
Agarwal P., Nieto Juan J., Luo M.-J.
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Anisotropic constitutive relationships in energetic materials: PETN and HMX [PDF]

, 2007
This paper presents results of first-principles density functional calculations of the equation of state (EOS) of PETN-I and beta-HMX. The isotropic EOS for hydrostatic compression has been extended to include uniaxial compressions in the [100], [010 ...
Conroy, M., Oleynik, I. I., White, C. T., Zybin, S. V.   +3 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Generalized Mittag-Leffler Distributions and Processes for Applications in Astrophysics and Time Series Modeling

, 2010
Geometric generalized Mittag-Leffler distributions having the Laplace transform $\frac{1}{1+\beta\log(1+t^\alpha)},00$ is introduced and its properties are discussed.
A Erdélyi, AG Pakes, AJ Lawrance, C Jacques, C Tsallis, CR Rao, DN Anderson, DN Dewald, DP Gaver, GD Lin, GD Lin, GD Lin, GD Lin, HJ Haubold, K Jayakumar, K Jayakumar, K Jayakumar, K Weron, L Devroye, LB Klebanov, RK Saxena, RK Saxena, RK Saxena, RN Pillai, RN Pillai, RN Pillai, RN Pillai, RN Pillai, S Kotz, S Kotz, TJ Kozubowski, TJ Kozubowski, V Seetha Lekshmi, V Seetha Lekshmi, Y Fujita   +34 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Renormalizable supersymmetric gauge theory in six dimensions

, 2005
We construct and discuss a 6D supersymmetric gauge theory involving four derivatives in the action. The theory involves a dimensionless coupling constant and is renormalizable.
A.V. Smilga, Aharony, Akama, Arutyunov, B.M. Zupnik, Bandos, Bastianelli, Claus, E.A. Ivanov, Galperin, Galperin, Galperin, Howe, Howe, Jackiw, Kazakov, Klaus, Koller, Macfarlane, Minwalla, Pasti, Randall, Rubakov, Seiberg, Smilga, Smilga, Strominger, Van Proeyen, Witten, Zupnik, Zupnik, Zupnik   +31 more
core   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source