Results 91 to 100 of about 1,873,772 (224)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Sugli effetti di ritorno della nostra creatività tecnica

open access: yesAisthesis, 2019
The essay aims to reflect on the question about how we become ourselves finding an answer in our species-specific technical creativity. By using the reflexions of Gilbert Simondon, Lambros Malafouris and Don Ihde, I want to suggest that through the ...
Elisa Binda
doaj   +1 more source

Extended Cognition and the Evolution of Human Language

open access: yes, 2020
The interaction between cognition and the environment may have shaped how human language developed over time. I consider the possibility that extended cognition contributed to the evolution of human language.
Amerson, Avery Brian
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Towards Extended Music Cognition: Commentary on "Music and Cognitive Extension"

open access: yesEmpirical Musicology Review, 2015
In his paper, Luke Kersten (2014) argues that since music cognition is part of a locationally wide computational system, it can be considered as an extended process. Overall I sympathize with Kersten's (2014) view.
Jakub Ryszard Matyja
doaj   +1 more source

The Mark of the Cognitive and the Coupling-Constitution Fallacy: A Defense of the Extended Mind Hypothesis

open access: yesFrontiers in Psychology, 2017
Clark and Chalmers (1998) introduced the extended mind hypothesis, according to which some mental states can be realized by non-biological external resources. A lively debate has flourished around this hypothesis, connected with the issues of embodiment,
Giulia Piredda
doaj   +1 more source

Music Cognition, Internalism and the Extended Mind [PDF]

open access: yes, 2014
This thesis aims to advance the study of music cognition by examining its philosophical foundations. It is argued that music cognition is problematically committed to a particular, questionable philosophical mode of thought about the mind and cognition ...
Kersten, Luke
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

The Multifunctionality of the Environment in Plant Interactions: Rethinking the Concept of ‘Environment’ and the Extended Cognition Hypothesis [PDF]

open access: yesLaboratorio dell'ISPF
This paper explores connections between studies on plant interactive abilities and (1) systemic-relational and ecological approaches, and (2) the framework of extended cognition.
Margherita BIANCHI
doaj   +1 more source

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