Results 71 to 80 of about 113,287 (282)
Extended cognition, personal responsibility, and relational autonomy
, 2010 The Hypothesis of Extended Cognition (HEC)-that many cognitive processes are carried out by a hybrid coalition of neural, bodily and environmental factors-entails that the intentional states that are reasons for action might best be ascribed to wider ...
Mason Cash, Cash, Mason
core +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Extended Circularity: A New Puzzle for Extended Cognition [PDF]
, 2018 Mainstream epistemology has typically presumed a traditional picture of the metaphysics of mind, whereby cognitive processes (e.g., memory storage and retrieval) play out within the bounds of skull and skin. Contemporary thinking in the philosophy of mind and cognitive science decreasingly favors this simple “intracranial” picture. Likewise, proponents
J. Adam Carter, Jesper Kallestrup
openaire +3 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
, 2013 Alongside existing research into the social, political and economic impacts of the Web, there is also a need to explore the effects of the Web on our cognitive profile.
Smart, Paul
core
"Involving Interface": An Extended Mind Theoretical Approach to Roboethics [PDF]
, 2010 In 2008 the authors held Involving Interface, a lively interdisciplinary event focusing on issues of biological, sociocultural, and technological interfacing (see Acknowledgments).
Tamami Fukushi +6 more
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Extended Memory, the Extended Mind, and the Nature of Technology-Mediated Memory Enhancement
, 2010 Human memory is a key focus of scientific and theoretical attention within a range of disciplines, and it is also an important target of efforts that seek to improve aspects of human cognitive function. The phenomenon of memory is also something that has
Smart, Paul
core
Culture and the Extended Phenotype: Cognition and Material Culture in Deep Time
, 2019 This chapter takes up the links between Dawkins’s concept of the extended phenotype and that of the extended mind. More specifically, it has three aims: (1) it argues that the extended mind effects are a special case of niche construction; (2) it ...
Sterelny, Kim
core +1 more source