Results 71 to 80 of about 1,873,772 (224)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
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Extended cognition and humility [PDF]
, 2020 Extended cognition is when cognitive processes extend beyond the brain and nervous system of the subject, and in the process properly include such ‘external’ devices as technology. This paper explores what relevance extended cognitive processes might have for humility, and especially for the specifically cognitive aspect of humility—viz., intellectual ...
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
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Extended Circularity: A New Puzzle for Extended Cognition [PDF]
, 2018 Mainstream epistemology has typically presumed a traditional picture of the metaphysics of mind, whereby cognitive processes (e.g., memory storage and retrieval) play out within the bounds of skull and skin. Contemporary thinking in the philosophy of mind and cognitive science decreasingly favors this simple “intracranial” picture. Likewise, proponents
J. Adam Carter, Jesper Kallestrup
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
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FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
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IEEJ Transactions on Electronics, Information and Systems, 1994 Fuzzy cognitive maps (FCMs) have been proposed to represent causal reasoning by using numeric processing. They graphically represent uncertain causal reasoning. In the resonant states, there emerges a limit cycle or a hidden pattern, which is a FCM inference.
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Expression and Extended Cognition [PDF]
Journal of Aesthetics and Art Criticism, 2008 It is typically granted that musical works can express emotions independently of the occurrent emotional states of their performers or composers. Yet while the performer or composer need not express his or her emotional state, it is still a value that may be effectively pursued, and for which music is highly suitable.
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Offloading cognition onto cognitive technology [PDF]
, 2008 "Cognizing" (e.g., thinking, understanding, and knowing) is a mental state. Systems without mental states, such as cognitive technology, can sometimes contribute to human cognition, but that does not make them cognizers.
Dror, I +5 more
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