Results 101 to 110 of about 2,902,174 (292)

Existence of non-exotic traversable wormholes in squared trace extended gravity theory

Nuclear Physics B
An extended gravity theory is used to explore the possibility of non-exotic matter traversable wormholes. In the extended gravity theory, additional terms linear and quadratic in the trace of the energy momentum tensor are considered in the Einstein ...
S.K. Tripathy, D. Nayak, B. Mishra, D. Behera, S.K. Sahu   +4 more
doaj   +1 more source

Robust Optimization of Energy Hubs Operation Based on Extended Affine Arithmetic

Energies, 2019
Traditional energy systems were planned and operated independently, but the diffusion of distributed and renewable energy systems led to the development of new modeling concepts, such as the energy hub.
Antonio Pepiciello, Alfredo Vaccaro, Mario Mañana   +2 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

A note on the von Bertalanffy growth function concerning the allocation of surplus energy to reproduction [PDF]

, 2012
We propose an extended form of the von Bertalanffy growth function (VBGF), where the allocation of surplus energy to reproduction is considered. Any function can be used in our model to describe the ratio of energy allocation for reproduction to that ...
Akamine, Tatsuro, Ohnishi, Shuhei, Okamura, Hiroshi, Yamakawa, Takashi   +3 more
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Dynamic Knowledge Management in an Agent-Based Extended Green Cloud Simulator

Energies
Cloud infrastructures operate in highly dynamic environments, and today, energy-focused optimization become crucial. Moreover, the concept of extended cloud infrastructure, which, among others, uses green energy, started to gain traction. This introduces
Zofia Wrona, Maria Ganzha, Marcin Paprzycki, Stanisław Krzyżanowski   +3 more
doaj   +1 more source

Proposal to detect an emission of unusual super-high energy electrons in electron storage rings

Results in Physics, 2014
According to an extended Lorentz–Einstein mass formula taken into the uncertainty principle, it is predicted that the electron beams passing accelerating electric field should with a small probability generate abnormal super-high energy electrons which ...
Da-peng Qian
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Energy Landscape and Dynamics of Biomolecules Extended Abstract [PDF]

Journal of Biological Physics, 2005
Proteins are not isolated homogeneous systems. Each protein can exist in a very large number of conformations (conformational substates) that are characterized by an energy landscape. The main conformational motions, similar to the α and β fluctuations in glasses, are linked to fluctuations in the bulk solvent and the hydration shell.
openaire   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source