Results 71 to 80 of about 2,902,174 (292)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Investigating Seidel energies and thermodynamic properties of benzenoid hydrocarbons through regression models

Scientific Reports
In this article, we present the concept of extended Seidel energy by employing a generalized extended matrix to study various molecular properties, including the Kovats retention index, boiling point, enthalpy of formation, entropy, acentric factor, and ...
Rashad Ismail, Hafiz Muhammad Bilal, Kiran Naz, Sarfraz Ahmad, Muhammad Kamran Siddiqui, Mustafa Ahmed Ali   +5 more
doaj   +1 more source

On the Extended Adjacency Eigenvalues of a Graph

Information
Let H be a graph of order n with m edges. Let di=d(vi) be the degree of the vertex vi. The extended adjacency matrix Aex(H) of H is an n×n matrix defined as Aex(H)=(bij), where bij=12didj+djdi, whenever vi and vj are adjacent and equal to zero otherwise.
Alaa Altassan, Hilal A. Ganie, Yilun Shang   +2 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Stochastic Calculus for Markov Processes Associated with Non-symmetric Dirichlet Forms

, 2011
Nakao's stochastic integrals for continuous additive functionals of zero energy are extended from the symmetric Dirichlet forms setting to the non-symmetric Dirichlet forms setting.
Chen, Chuan-Zhong, Ma, Li, Sun, Wei
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Prospects for Extending the Core-collapse Supernova Detection Horizon Using High-energy Neutrinos

The Astrophysical Journal, 2023
Large neutrino detectors like IceCube monitor for core-collapse supernovae using low-energy (MeV) neutrinos with a detection reach from a supernova neutrino burst to the Magellanic Cloud. However, some models predict the emission of high-energy neutrinos
Nora Valtonen-Mattila, Erin O’Sullivan
doaj   +1 more source

Speedup in Quantum Adiabatic Evolution Algorithm

, 2002
Quantum adiabatic evolution algorithm suggested by Farhi et al. was effective in solving instances of NP-complete problems. The algorithm is governed by the adiabatic theorem. Therefore, in order to reduce the running time, it is essential to examine the
Bae, Joonwoo, Kwon, Younghun
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source