Results 171 to 180 of about 40,502 (261)

A comprehensive review of cluster methods for drug–drug interaction network

Quantitative Biology, Volume 14, Issue 1, March 2026.
Abstract The detection of drug–drug interaction (DDI) is crucial to the rational use of drug combinations. Experimentally, DDI detection is time‐consuming and laborious. Currently, researchers have developed a variety of computational methods to predict DDI.
Shuyuan Cao, Guixia Liu, Xiangrun Zhou, Ji Lv   +3 more
wiley   +1 more source

Spatial joint profiling of DNA methylome and transcriptome in tissues. [PDF]

Nature
Lee CN, Fu H, Cardilla A, Zhou W, Deng Y.   +4 more
europepmc   +1 more source

Toward Psychometric Learning Analytics: Augmenting the Urnings Algorithm with Response Times

Journal of Educational Measurement, Volume 63, Issue 1, Spring 2026.
Abstract Adaptive learning systems (ALS) aim to tailor the educational material to match the student's needs, ultimately improving the learning outcomes. An ALS dynamically adjust the level of practice based on the student's ability; therefore, obtaining accurate ability estimates is crucial.
Bence Gergely, Maria Bolsinova
wiley   +1 more source

A Review: Construction of Statistical Distributions. [PDF]

Entropy (Basel)
Fang KT, Lin YX, Deng YH.
europepmc   +1 more source

GENERATING FUNCTIONS FOR THE EXTENDED WRIGHT TYPE HYPERGEOMETRIC FUNCTION

Communications of the Korean Mathematical Society, 2017
Ranjan Kumar Jana, Bhumika Maheshwari, Ajay Kumar Shukla   +2 more
openaire   +2 more sources

Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer

Advanced Science, Volume 13, Issue 8, 9 February 2026.
YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang, Qingwen Huang, Zhuo Chen, Weijian Meng, Hongliang Dong, Zhihong Qi, Liang Liu, Jie Shen, Daxing Xie   +8 more
wiley   +1 more source

Beyond synthetic lethality in large-scale metabolic and regulatory network models via genetic minimal intervention set. [PDF]

Bioinform Adv
Barrena N, Rodriguez-Flores C, Valcárcel LV, Olaverri-Mendizabal D, Agirre X, Prósper F, Planes FJ.   +6 more
europepmc   +1 more source

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, Volume 13, Issue 7, 3 February 2026.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

Genetics and environment distinctively shape the human immune cell epigenome. [PDF]

Nat Genet
Wang W, Hariharan M, Ding W, Bartlett A, Barragan C, Castanon R, Wang R, Rothenberg V, Song H, Nery JR, Aldridge A, Altshul J, Kenworthy M, Liu H, Tian W, Zhou J, Zeng Q, Chen H, Wei B, Gündüz IB, Norell T, Broderick TJ, McClain MT, Satterwhite LL, Burke TW, Petzold EA, Shen X, Woods CW, Fowler VG, Ruffin F, Panuwet P, Barr DB, Beare JL, Smith AK, Spurbeck RR, Vangeti S, Ramos I, Nudelman G, Sealfon SC, Castellino F, Walley AM, Evans T, Müller F, Greenleaf WJ, Ecker JR.   +44 more
europepmc   +1 more source

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, Volume 13, Issue 7, 3 February 2026.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source