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Pharmacotherapy, 2011 STUDY OBJECTIVE: To compare the effectiveness of extended-infusion piperacillin-tazobactam with that of similar-spectrum, nonextended-infusion [H9252]-lactam antibiotics in the treatment of gram-negative infections.
Raymond Yost
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National survey on continuous and extended infusions of antibiotics
American Journal of Health-System Pharmacy, 2012A national survey was conducted to evaluate the use of continuous and extended infusions for administering β-lactams and vancomycin.The survey was sent to a random sample of 1000 acute care hospital pharmacists in the United States to evaluate the use of continuous and extended infusions of antibiotics.
Jomy M, George +2 more
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Rationale and evidence for extended infusion of piperacillin–tazobactam
American Journal of Health-System Pharmacy, 2011The pharmacodynamics and therapeutic effects of extended-infusion (EI) piperacillin-tazobactam therapy are reviewed, with an emphasis on growing evidence of its advantages over traditional infusion schemes.EI β-lactam therapy is now considered a key aspect of antimicrobial stewardship, and published evidence indicates that i.v. infusion of piperacillin-
Scott E, Kaufman +2 more
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Extended infusion compared to standard infusion cefepime as empiric treatment of febrile neutropenia
Journal of Oncology Pharmacy Practice, 2017Background Extended infusion (EI) dosing provides a longer time above the minimum inhibitory concentration, which is important for the clinical success of β-lactam antibiotics, especially for patients with impaired immunity.
Rebekah H, Wrenn +4 more
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A Review of Extended and Continuous Infusion Beta-Lactams in Pediatric Patients
The Journal of Pediatric Pharmacology and Therapeutics, 2022Intravenous beta-lactam antibiotics are the most prescribed antibiotic class in US hospitalized patients of all ages; therefore, optimizing their dosing is crucial. Bactericidal killing is best predicted by the time in which beta-lactam drug concentrations are maintained above the organism's minimum inhibitory concentration (MIC), rather than ...
Imburgia, Taylor A., Kussin, Michelle L.
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Clinical outcomes of cefepime extended infusions
The American Journal of the Medical SciencesCefepime, a fourth-generation cephalosporin, has traditionally been administered via 30-minute standard infusions. However, an extended infusion of cefepime, administered over 3-4 h, has demonstrated improved pharmacodynamic target attainment. This narrative review evaluates the clinical impact of extended infusion cefepime across diverse infections ...
Aaron, Shaykevich +2 more
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Outcomes of Extended Infusion Cefepime in Pediatric Patients
Infectious Diseases in Clinical Practice, 2019Background Extended infusions of cefepime optimize pharmacokinetic and pharmacodynamic parameters and improve clinical outcomes in adults with gram-negative infections, but there are no similar studies in children. The objective of this study was to compare clinical outcomes in children receiving extended and traditional ...
Lauren C. Beauchamp +2 more
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Continuous and Extended Infusions of β-Lactam Antibiotics in the Pediatric Population
Annals of Pharmacotherapy, 2012OBJECTIVE: To conduct a systematic review of available data on the use of extended or continuous infusion of β-lactam and monobactam therapy in the pediatric population (aged 0–18 years). DATA SOURCES: A literature search was performed
Mary Covington, Walker +2 more
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Ambulatory antibiotic infusion devices: Extending the spectrum of outpatient therapies
The American Journal of Medicine, 1991To examine the safety and efficacy, as well as the economic impact, of outpatient intravenous antibiotic administration using an ambulatory infusion pump.Retrospective analysis of patients treated through a single home care pharmacy.General community and skilled nursing facilities of the greater Monterey (California) area.Ninety-eight consecutive ...
P B, New +3 more
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Journal of Clinical Oncology, 2023
e21083 Background: Initial results with amivantamab (ami) in CHRYSALIS-1, and ami and lazertinib (laz) regimen in CHRYSALIS-2 showed encouraging efficacy in patients whose disease progressed after standard-of-care chemotherapy, and osimertinib (osi) and platinum-based chemotherapy respectively.
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e21083 Background: Initial results with amivantamab (ami) in CHRYSALIS-1, and ami and lazertinib (laz) regimen in CHRYSALIS-2 showed encouraging efficacy in patients whose disease progressed after standard-of-care chemotherapy, and osimertinib (osi) and platinum-based chemotherapy respectively.
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