Results 1 to 10 of about 231,927 (216)

Pharmacokinetics of imipenem in critically ill patients: Continuous infusion versus extended infusion in a real-world study [PDF]

Journal of International Medical Research
Objective This study compared the pharmacokinetic/pharmacodynamic properties of extended infusion and continuous infusion of imipenem at equivalent daily doses in a real-world setting.
Ruixia Zhang, Yi Qin, Yayao Lv, Yi Zhang
doaj   +2 more sources

Rationale and Logistics of Continuous Infusion Cephalosporin Antibiotics [PDF]

Pharmacy
Cephalosporins have traditionally been administered as an intermittent infusion. With the knowledge that cephalosporins demonstrate a time-dependent pharmacodynamic profile, administration via continuous infusion may provide more effective antibiotic ...
Abbie L. Blunier, R. Jake Crocker, Rachel Foster, Stephanie S. May, Caroline E. Powers, P. Brandon Bookstaver   +5 more
doaj   +2 more sources

A Mathematical Model for Comparison of Bolus Injection, Continuous Infusion, and Liposomal Delivery of Doxorubicin to Tumor Cells

Neoplasia: An International Journal for Oncology Research, 2000
Determining the optimal mode of delivery for doxorubicin is important given the wide use of the drug against many tumor types. The relative performances of bolus injection, continuous infusion, liposomal and thermoliposomal delivery are not yet ...
Ardith W. El-Kareh, Timothy W. Secomb
doaj   +3 more sources

Effectiveness of Extended or Continuous vs. Bolus Infusion of Broad-Spectrum Beta-Lactam Antibiotics for Febrile Neutropenia: A Systematic Review and Meta-Analysis

Antibiotics, 2023
This systematic review aimed to compare extended infusion or continuous infusion with bolus infusion for febrile neutropenia (FN). We included clinical trials comparing extended or continuous infusion with bolus infusion of beta-lactam antibiotics as ...
Kazuhiro Ishikawa, Koko Shibutani, Fujimi Kawai, Erika Ota, Osamu Takahashi, Nobuyoshi Mori   +5 more
doaj   +1 more source

Continuous wound infusion as an alternative to continuous epidural infusion for postoperative analgesia in renal transplant surgery: A prospective randomized controlled trial

Indian Journal of Transplantation, 2021
Background: Pain management is often challenging in patients undergoing renal transplant owing to the various comorbidities. Epidural analgesia is currently the standard technique but is not without complications.
Vinitha Narayan, Sameer Sethi, Kamal Kajal, Sarbpreet Singh   +3 more
doaj   +1 more source

Continuous IV infusion of anakinra

Frontiers in Pharmacology, 2023
Objective: A review of the use of continuous IV infusion of anakinra; a description of the protocol for continuous IV infusion of anakinra in the treatment of cytokine storm developed over the past 4 years at a tertiary level academic medical center in ...
Brittney N. Saunders, Marcela V. Kuijpers, Jason J. Sloan, Elie Gertner   +3 more
doaj   +1 more source

Optimizing Betalactam Clinical Response by Using a Continuous Infusion: A Comprehensive Review

Antibiotics, 2023
Introduction: Antimicrobial resistance is a major healthcare issue responsible for a large number of deaths. Many reviews identified that PKPD data are in favor of the use of continuous infusion, and we wanted to review clinical data results in order to ...
Sylvain Diamantis, Catherine Chakvetadze, Astrid de Pontfarcy, Matta Matta   +3 more
doaj   +1 more source

Continuous infusion versus intermittent infusion of vancomycin in critically ill patients undergoing continuous venovenous hemofiltration: a prospective interventional study

BMC Infectious Diseases, 2022
Background A prospective interventional study comparing outcomes in critically ill patients receiving intermittent infusion (II) or continuous infusion (CI) of vancomycin during continuous venovenous hemofiltration (CVVH) is lacking.
Jinhui Xu, Lufen Duan, Jiahui Li, Fang Chen, Xiaowen Xu, Jian Lu, Zhiwei Zhuang, Yifei Cao, Yunlong Yuan, Xin Liu, Jiantong Sun, Qin Zhou, Lu Shi, Lian Tang   +13 more
doaj   +1 more source

Continuous Piperacillin-Tazobactam Infusion Improves Clinical Outcomes in Critically Ill Patients with Sepsis: A Retrospective, Single-Centre Study

Antibiotics, 2022
Continuous infusion of beta-lactam antibiotics has emerged as an alternative for the treatment of sepsis because of the favourable pharmacokinetics of continuous infusion. This study aimed to evaluate the survival benefits of continuous vs.
Dong-gon Hyun, Jarim Seo, Su Yeon Lee, Jee Hwan Ahn, Sang-Bum Hong, Chae-Man Lim, Younsuck Koh, Jin Won Huh   +7 more
doaj   +1 more source

Comparison of intermittent versus continuous-infusion vancomycin for treating severe patients in intensive care units

Brazilian Journal of Infectious Diseases, 2020
Purpose: The aim of this study was to compare pharmacokinetic characteristics between intermittent infusion and continuous infusion of vancomycin for critically ill patients admitted to intensive care units. Methods: Intermittent therapy was administered
Carolina Hikari Yamada, João Paulo Telles, Dayana dos Santos Oliveira, Juliette Cieslinski, Victoria Stadler Tasca Ribeiro, Juliano Gasparetto, Felipe Francisco Tuon   +6 more
doaj   +1 more source