Results 41 to 50 of about 2,169,201 (257)

Intermittent saline flushes or continuous saline infusion: what works better when heparin-free dialysis is recommended? [PDF]

, 2013
Edward Zimbudzi Department of Nephrology, Monash Health, Monash Medical Centre, Clayton, Melbourne, VIC, Australia Introduction: Coagulation-free dialysis, also commonly known as “heparin-free” dialysis, can be a challenging procedure as it ...
Zimbudzi E
core  

Continuous versus Intermittent Bolus Epidural Anaesthesia in Elderly Surgical Patients

Journal of Nepal Medical Association, 2003
A prospective study of 70 elderly conventionally continuously randomized patients was done to compare the haemodynamic changes produced during continuous infusion versus intermittent bolus epidural anaesthesia. The hemodynamic parameters (Blood pressure,
XK Yin, ZG Xiang, A Prasai, N Lamichhane
doaj   +1 more source

continuous versus conventional infusion of amphotericin B deoxycholate: a meta-analysis. [PDF]

PLoS ONE, 2013
BACKGROUND: Treatment with Amphotericin B (AmB) deoxycholate, which is still used widely, particularly in low-resource countries, has been challenged due to nephrotoxicity.
Matthew E Falagas, Drosos E Karageorgopoulos, Giannoula S Tansarli   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Continuous intravenous lidocaine infusion during isoflurane anaesthesia in horses undergoing surgical procedures

, 2012
The aim of the present study was to evaluate the adjunction of lidocaine as a continuous intravenous (IV) infusion during general anaesthesia with isoflurane in a clinical setting.
Levionnois, O, Spadavecchia, C, Schuhbeck, M M, Kuhn, M   +3 more
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Detection of subclinical cardiotoxicity in sarcoma patients receiving continuous doxorubicin infusion or pre-treatment with dexrazoxane before bolus doxorubicin

Cardio-Oncology, 2020
Background Continuous infusion of doxorubicin or dexrazoxane pre-treatment prior to bolus doxorubicin are proven strategies to protect against doxorubicin-induced cardiotoxicity.
Jieli Li, Hui-Ming Chang, Jose Banchs, Dejka M. Araujo, Saamir A. Hassan, Elizabeth A. Wagar, Edward T. H. Yeh, Qing H. Meng   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Continuous infusion versus intermittent bolus furosemide in heart failure NYHA III-IV [PDF]

, 2017
The study was designed to investigate the therapeutic effect of Continuous Infusion (CI) and Intermittent Bolus (IB) administration of furosemide on patients with NYHA class III-IV heart failure hospitalized in Dr. Soetomo Hospital Surabaya.
Samirah, -, S. Sjamsiah, -, M. Yogiarto
core   +1 more source