Results 51 to 60 of about 2,169,201 (257)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Role of Continuous Infusion Loop Diuretics

, 1995
Objective: To evaluate the role of continuous infusion loop diuretics in selected patient populations, discuss the advantages and disadvantages associated with continuous infusion, and recommend monitoring parameters for the use of continuous infusion ...
Melissa A Gaylor, Shannon L Yelton, Kim M Murray   +2 more
core   +1 more source

Continuous subcutaneous insulin infusion: practical issues

Indian Journal of Endocrinology and Metabolism, 2012
The growing number of individuals with diabetes mellitus has prompted new way of treating these patients, continuous subcutaneous insulin infusion (CSII) or insulin pump therapy is an increasingly form of intensive insulin therapy.
Banshi D Saboo, Praful A Talaviya
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Continuous infusion in rats

, 1964
A simple method of continuous intravascular infusion is described that involves little trauma and is tolerated by pregnant rats. The mechanism is a polyethylene catheter in the tail vein, an accommodating cage in which the rat can move freely, and a ...
A. L. Kennan
core   +1 more source

Continuous versus intermittent infusion of high-dose meropenem in critically ill patients: an observational cohort study

International Journal of Infectious Diseases
Background: Whether continuous infusion of high-dose meropenem improves outcomes compared with intermittent infusion in critically ill patients remains unclear.
Felix Bergmann, Marlene Prager, Katarina Kumpf, Iris K. Minichmayr, Georg Gelbenegger, Lena Pracher, Markus Zeitlinger, Anselm Jorda   +7 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Contribution of liver nerves, glucagon, and adrenaline to the glycaemic response to exercise in rats [PDF]

, 1994
The contribution of hepatic sympathetic innervation, glucagon and adrenaline to the glycaemic response to exercise was investigated in rats. Hepatically denervated (LDX) or sham operated (SHAM) rats with permanent catheters were therefore submitted to ...
B. AHRÉN, Dijk, G. van,, Bouws, G., van Dijk, Gertjan; id_orcid, Ahrén, B., Lindfeldt, J., KUVAKİ BALKAN, BAHAR, Bouws, G.,, SCHEURINK, AJW, AHREN, B, Balkan, B.,, Balkan, B., A. J. W. SCHEURINK, VAN DIJK, G, BOUWS, G, LINDFELDT, J, Scheurink, A.J.W., BALKAN, B, STEFFENS, AB, G. BOUWS, Steffens, A.B.,, B. BALKAN, Ahrén, B.,, Scheurink, A.J.W.,, A. B. STEFFENS, Steffens, A.B., Lindfeldt, J.,, G. VAN DIJK, van Dijk, Gertjan, VANDIJK, G, J. LINDFELDT   +30 more
core   +2 more sources

Continuous wound infusion catheter as part of a multimodal analgesia regimen for post-Caesarean delivery pain: a quality improvement impact study

BJA Open
Background: The role of continuous wound infusion catheters as part of a multimodal analgesia strategy after Caesarean delivery is unclear. We introduced continuous wound infusion catheters to our multimodal analgesia regimen to evaluate the impact on ...
Cedar Fowler, Emily Stockert, Dan Hoang, Nan Guo, Edward Riley, Pervez Sultan, Brendan Carvalho   +6 more
doaj   +1 more source