Results 81 to 90 of about 1,491,973 (279)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Consciousness and Cosmos: Building an Ontological Framework [PDF]

, 2018
Contemporary theories of consciousness are based on widely different concepts of its nature, most or all of which probably embody aspects of the truth about it. Starting with a concept of consciousness indicated by the phrase “the feeling of what happens”
Nixon, Greg, Nunn, Chris, Pereira Jr, Alfredo, Pregnolato, Massimo   +3 more
core  

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Black Holes, Branes and Superconformal Symmetry

, 1999
The main focus of this lecture is on extended objects in adS*S bosonic backgrounds with unbroken supersymmetry. The backgrounds are argued to be exact, special consideration are given to the non-maximal supersymmetry case.
A. Galperin, C. Vafa, D. Amati, E. Cremmer, G. W. Gibbons, J. M. Maldacena, J. Schwarz, K. M. Case, L. Brink, M.T. Grisaru, P. Claus, P. Claus, P. S. Howe, R. Güven, R. Kallosh, R. Kallosh, R. Kallosh, R.R. Metsaev, S. Ferrara, S. Ferrara, S. Fubini, V. Alfaro de, V.P. Akulov   +22 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Extended Reality Training Analytical Transcends in The Future Digital Society [PDF]

, 2019
Report published in the Proceedings of the National Conference on "Education and Research in the Information Society", Plovdiv, May, 2019The upcoming digital Society 5.0 is expected to give a more creative role to the new digitally (i-) transformed ...
Minchev, Zlatogor
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Absence of a metallic phase in random-bond Ising models in two dimensions: applications to disordered superconductors and paired quantum Hall states

, 2000
When the two-dimensional random-bond Ising model is represented as a noninteracting fermion problem, it has the same symmetries as an ensemble of random matrices known as class D.
A. Altland, A.J. Bray, A.W.W. Ludwig, Andreas W. W. Ludwig, D.S. Fisher, D.S. Fisher, H. Nishimori, I.A. Gruzberg, J. Cardy, J.A. Blackman, J.A. Blackman, J.T. Chalker, K. Binder, L. Dixon, L. Kadanoff, M. Bocquet, M.R. Zirnbauer, N. Kawashima, N. Read, N. Read, P. Le Doussal, P. Le Doussal, P.W. Brouwer, R. Bundschuh, R.J. Baxter, S. Cho, S. Vishveshwara, T. Senthil, T. Senthil, T. Senthil, V. Kagalovsky, W.L. McMillan   +31 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source