Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
An extended state observer based U-model control of the COVID-19. [PDF]
ISA Trans, 2022 Wei W, Duan B, Zuo M, Zhu Q.
europepmc +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
A Finite-Time Fractional-Order Error Extended State Observer for Hypersonic Vehicle
International Journal of Aerospace EngineeringTo address the challenges posed by strong coupling, nonlinearity, and rapid time-varying dynamics in hypersonic vehicle (HV), this study presents an active disturbance rejection control (ADRC) scheme based on finite-time fractional-order error extended ...
Mingfei Zhao +3 more
doaj +1 more source
Event-triggered impulsive observer with K-asymptotic gain for DC microgrids
International Journal of Electrical Power & Energy SystemsThis paper studies the problem of the state estimate of a class of DC microgrids with both disturbed states and disturbed outputs via event-triggered impulsive observer (ETIO).
Zhou-Teng Xie +3 more
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Improved Nonlinear Extended State Observer-Based Sliding-Mode Rotary Control for the Rotation System of a Hydraulic Roofbolter. [PDF]
Entropy (Basel), 2021 Zhang Z, Guo Y, Song X.
europepmc +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Model and Data-Driven Combination: A Fault Diagnosis and Localization Method for Unknown Fault Size of Quadrotor UAV Actuator Based on Extended State Observer and Deep Forest. [PDF]
Sensors (Basel), 2022 Song J, Shang W, Ai S, Zhao K.
europepmc +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source