Results 111 to 120 of about 16,236 (260)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Improved sliding mode path tracking control for automated guided vehicles with the disturbances compensation

International Journal of Advanced Robotic Systems
This article investigates the path tracking problem for the two-wheel differential drive automated guided vehicles (AGVs) under the influence of unknown disturbances. Firstly, a state observer and a radial basis function (RBF) neural network are combined
Jun Nie, Xinyu Zhang, Chunyang Sheng, Haixia Wang, Xiao Lu   +4 more
doaj   +1 more source

A cyclic bipolar wind in the interacting binary V393 Scorpii

, 2012
V393 Scorpii is a Double Periodic Variable characterized by a relatively stable non-orbital photometric cycle of 253 days. Mennickent et al. argue for the presence of a massive optically thick disc around the more massive B-type component and describe ...
Bevington, Castelli, Charbonneau, E. Niemczura, Eggleton, Featherstone, G. Djurasevic, G. J. Peters, Gebbie, Harmanec, Herbig, I. Araya, Israelian, Kreiner, Lucy, M. Curé, M. Diaz, Marsh, Mennickent, Mennickent, Mennickent, Mennickent, Mennickent, Mennickent, Mennickent, Mennickent, Moss, Munari, Peters, Peters, Peterson, Pilecki, Poeckert, Pojmanski, Poleski, R. E. Mennickent, Richards, Richards, Rosenfeld, Sarna, Sbordone, Schulte-Ladbeck, Skul'Skij, Stewart, van Rensbergen, Weselak, Z. Kołaczkowski, Zahn, Zahn   +48 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A Lyman-alpha-only AGN from the Sloan Digital Sky Survey

, 2004
The Sloan Digital Sky Survey has discovered a z=2.4917 radio-loud active galactic nucleus (AGN) with a luminous, variable, low-polarization UV continuum, H I two-photon emission, and a moderately broad Lyman-alpha line (FWHM = 1430 km/s) but without ...
Atsuko Nitta, Bergeron J., Bremer M. N., Brenda Frye, Bunker A., Christy A. Tremonti, Damien Hutsemékers, Daniel C. Long, Daniel E. Vanden Berk, David J. Schlegel, De Breuck C., Donald G. York, Donald P. Schneider, Eric Neilsen, Erik A. Hoversten, Gillian R. Knapp, J. Brinkmann, Jurek Krzesinski, Karl Glazebrook, Manzini A., Martin Niederste-Ostholt, Masataka Fukugita, Michael A. Strauss, Michael Harvanek, P. R. Newman, Patrick B. Hall, Pentericci L., S. Kleinman, S. Snedden, Timothy M. Heckman, van Ojik R., Željko Ivezić   +31 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source