Results 111 to 120 of about 175,766 (297)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A Semantic Base for the Fuzzy Extension-Principle

, 2012
A distance/semantic is attached to fuzzy acceptabilities. Within the frame of this semantic, a modified version of the extension principle proves to be obligatory.
Becker, H.
core  

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Harnack Inequalities and ABP Estimates for Nonlinear Second-Order Elliptic Equations in Unbounded Domains

Abstract and Applied Analysis, 2008
We are concerned with fully nonlinear uniformly elliptic operators with a superlinear gradient term. We look for local estimates, such as weak Harnack inequality and local maximum principle, and their extension up to the boundary.
M. E. Amendola, L. Rossi, A. Vitolo
doaj   +1 more source

Extension of Banach Cotraction Principle for Cone Metric space

, 2018
In this paper an extension of Banach contraction principle is introdues for the rational contraction in cone metric space.
Shrivastava, Rajesh, Khare, Swati
core  

Comparison principle for positive time-delay systems: An extension and its application

, 2021
Comparison principle for positive time-delay systems: An extension and its ...
LQ Thuan (15822959), TN Nguyen (9608171), PT Nam (14529869), Hieu Trinh (13073460)   +3 more
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Classical Correspondence of Squeezing Operators and the Extension of Bohr’s Correspondence Principle

Photonics
Bohr’s correspondence principle acts as a link between quantum physics and classical physics theory, while squeezed light, as a special nonclassical quantum state in quantum physics, achieves precision measurements and gravitational wave detection by ...
Ke Zhang, Hongyi Fan
doaj   +1 more source