CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
wiley +1 more source
Correction: New targets in diabetic retinopathy: addressing limitations of current treatments through the Sema3A/Nrp1 pathway. [PDF]
Sivaprasad S +6 more
europepmc +1 more source
The Effects of a Limited Extensive Reading Program [PDF]
Hisayo HERBERT, ハーバート 久代
core +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
Investigating the Implementation of Extensive Reading in Four Asian Countries
Mintra Puripunyavanich, Rob Waring
openalex +2 more sources
Overview of molecular signatures of senescence and associated resources: pros and cons
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
The pediatrician's role in the follow-up of children/adolescents with mental and/or neurodevelopmental disorders. [PDF]
Nunes ML.
europepmc +1 more source
The use of extensive reading method to improve students' motivation in learning English at grade eight of SMP Darul Rohman Morombuh Kwanyar Bangkalan [PDF]
Nurah Nurah
openalex

