Results 81 to 90 of about 1,617,890 (331)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Extensive reading in primary school EFL

Acta Didactica Norge, 2018
Reading in the English subject in both primary and secondary school often involves studying course book texts in detail. Therefore, pupils are rarely exposed to longer texts which require reading for meaning, a skill needed in higher education and ...
Anna Birketveit, Hege Emma Rimmereide, Monika Bader, Linda Fisher   +3 more
doaj   +1 more source

INVESTING IN ACADEMIC SPEAKING THROUGH GUIDED EXTENSIVE READING A CASE STUDY IN EXTENSIVE READING CLASS AT ENGLISH DEPARTMENT MATARAM UNIVERSITY INDONESIA [PDF]

, 2016
One principle of Extensive Reading (ER) as Day and Bamford (2002) have pointed out is that ER should be oriented to help students to be self-motivated readers by giving them freedom to choose reading materials that interest them.
Lestari, Yuni Budi, Yusra, Kamaludin
core  

Extensive translation of small Open Reading Frames revealed by Poly-Ribo-Seq [PDF]

, 2014
Thousands of small Open Reading Frames (smORFs) with the potential to encode small peptides of fewer than 100 amino acids exist in our genomes. However, the number of smORFs actually translated, and their molecular and functional roles are still unclear.
Andrews, Arava, Basrai, Bazzini, Boerjan, Brunner, Chew, Child, Chou, Crappe, Derrien, Djakovic, Duncan, Dunn, Eden, Falth, Frith, Fritsch, Galindo, Guttman, Hanada, Hanyu-Nakamura, Hemm, Ingolia, Ingolia, Ingolia, Kastenmayer, King, Kondo, Kozak, Krogh, Kulkarni, Kumar, Ladoukakis, Lemaitre, Magny, Pauli, Pueyo, Schmidt, Schneider, Siepel, Slavoff, Smith, Tripoli, Volders, Wilson   +45 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

PENGGUNAAN INTERNET DALAM PEMBELAJARAN EXTENSIVE READING [PDF]

, 2009
Extensive Reading adalah membaca sejumlah besar bacaan untuk mendapatkan informasi dan kesenangan. Program Extensive reading telah ada di seluruh dunia selama bertahun-tahun dengan sejumlah nama berbeda, seperti Book Flood, Uninterrupted Sustained Silent
Hati, Gita Mutiara
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Lessons Learned While Managing My First Book Club

Studies in Self-Access Learning Journal, 2011
Extensive reading has become a popular way to promote language development. I had long wanted to introduce my students to pleasure reading as a means to improve their English, but because I was only teaching conversation courses, I saw no opportunity to ...
Holly Marland
doaj  

Improving Students’ Vocabulary Acquisition and Reading Comprehension by Using the Extensive Reading Approach at Grade 8 of SMP Negeri 2 Silima Punggapungga Dairi

Journal of English Teaching and Applied Linguistics
This study investigates the effectiveness of the Extensive Reading approach in improving vocabulary acquisition and reading comprehension among eighth-grade students at SMP Negeri 2 Silima Punggapungga.
Fransisca Simanjuntak, Lastri Wahyuni Manurung   +1 more
doaj   +1 more source