Results 81 to 90 of about 1,620,578 (347)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Extensive reading in primary school EFL
Acta Didactica Norge, 2018 Reading in the English subject in both primary and secondary school often involves studying course book texts in detail. Therefore, pupils are rarely exposed to longer texts which require reading for meaning, a skill needed in higher education and ...
Anna Birketveit +3 more
doaj +1 more source
, 2015 NeXML is a powerful and extensible exchange standard recently proposed to better meet the expanding needs for phylogenetic data and metadata sharing. Here we present the RNeXML package, which provides users of the R programming language with easy-to-use ...
Boettiger, Carl +3 more
core +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Journal of English Teaching and Applied LinguisticsThis study investigates the effectiveness of the Extensive Reading approach in improving vocabulary acquisition and reading comprehension among eighth-grade students at SMP Negeri 2 Silima Punggapungga.
Fransisca Simanjuntak +1 more
doaj +1 more source
You’ve Gotta Read This! Connecting with Readers at an Academic Library
, 2014 At our small, liberal arts college, the library has developed a vibrant browsing collection of popular fiction and nonfiction titles in both print and ebook formats.
Baugess, Clinton K. +1 more
core
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Lessons Learned While Managing My First Book Club
Studies in Self-Access Learning Journal, 2011 Extensive reading has become a popular way to promote language development. I had long wanted to introduce my students to pleasure reading as a means to improve their English, but because I was only teaching conversation courses, I saw no opportunity to ...
Holly Marland
doaj
Designing reading tasks to maximise vocabulary learning [PDF]
Applied Research on English Language, 2014 Most vocabulary learning should occur incidentally through listening and reading. This is one of the reasons why a substantial extensive reading program is an important part of an English course.
Paul Nation
doaj