Results 61 to 70 of about 2,978,826 (285)

Drug-Resistant Tuberculosis and HIV Infection: Current Perspectives

HIV/AIDS: Research and Palliative Care, 2020
Abhijeet Singh, 1 Rajendra Prasad, 1, 2 Viswesvaran Balasubramanian, 1 Nikhil Gupta 3 1Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, New Delhi, Delhi 110007, India; 2Department of Pulmonary Medicine, King ...
Singh A, Prasad R, Balasubramanian V, Gupta N   +3 more
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Extensively drug resistant tuberculosis in Mali: a case report

BMC Research Notes, 2017
Background Drug resistant tuberculosis presents a major public health challenge. Case presentation We present here the first two patients diagnosed with extensively drug resistant tuberculosis in Bamako, Mali.
Bassirou Diarra, Yacouba Toloba, Bakary Konate, Moumine Sanogo, Antieme Combo Georges Togo, Fatimata Camara, Gaoussou Berthe, Dianguina Soumaré, Bocar Baya, Drissa Goita, Yeya dit Sadio Sarro, Mamoudou Maiga, Michael Belson, Susan Orsega, Sounkalo Dao, Robert L. Murphy, Sophia Siddiqui, Bouke C. de Jong, Seydou Doumbia, Souleymane Diallo   +19 more
doaj   +1 more source

Extensively drug-resistant typhoid fever in Pakistan [PDF]

The Lancet Infectious Diseases, 2019
We read the Article by Farah Qamar and colleagues about the outbreak of ceftriaxone-resistant Salmonella enterica serotype Typhi in Hyderabad, Pakistan, with great interest. S Typhi was observed as being twice as prevalent in the Qasimabad subdistrict of Hyderabad City (attack rate 15 per 1000 residents) as in the Latifabad subdistrict (seven per 1000 ...
Muhammad Kamran Rasheed, Syed Shahzad Hasan, Zaheer-Ud-Din Babar, Syed Imran Ahmed   +3 more
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Averting epidemics of extensively drug-resistant tuberculosis [PDF]

Proceedings of the National Academy of Sciences, 2009
Extensively drug-resistant tuberculosis (XDR TB) has been detected in most provinces of South Africa, particularly in the KwaZulu-Natal province where several hundred cases have been reported since 2004. We analyzed the transmission dynamics of XDR TB in the region using mathematical models, and observed that nosocomial transmission clusters of XDR TB ...
Sanjay, Basu, Gerald H, Friedland, Jan, Medlock, Jason R, Andrews, N Sarita, Shah, Neel R, Gandhi, Anthony, Moll, Prashini, Moodley, A Willem, Sturm, Alison P, Galvani   +9 more
openaire   +2 more sources

Extensively Drug-Resistant Stenotrophomonas Maltophilia in a Tertiary Care Hospital in Taiwan: Microbiologic Characteristics, Clinical Features, and Outcomes

, 2009
A retrospective study was performed in a university- affiliated referral center from year 1999 to year 2004 to understand the trend of resistance in Stenotrophomonas maltophilia isolates associated with nosocomial infections and describe the emergence of
陳志金;廖淑貞;余忠仁;鄧麗珍;薛博仁, TAN, CHE-KIM;LIAW, SHWU-JEN;YU, CHONG- JEN;TENG, LEE-JENE;HSUEH, PO-REN   +1 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues [PDF]

, 2013
Defining the pharmacological target(s) of currently used drugs and developing new analogues with greater potency are both important aspects of the search for agents that are effective against drug-sensitive and drug-resistant Mycobacterium tuberculosis ...
Vialla, Emilie, Gannoun-Zaki, Laila, Kremer, Laurent, Craig, Derek, Coxon, Geoffrey, Corrales, Rosa Milagros   +5 more
core   +4 more sources

Multidrug-Resistant and Extensively Drug-Resistant Enterobacteriaceae: Prevalence, Treatments, and Outcomes – A Retrospective Cohort Study

Infection and Drug Resistance, 2020
Hadeel Alkofide,1 Abdullah M Alhammad,1,2 Alya Alruwaili,3 Ahmed Aldemerdash,1 Thamer A Almangour,1 Aseel Alsuwayegh,2 Daad Almoqbel,4 Aljohara Albati,5 Aljohara Alsaud,6 Mushira Enani7 1Department of Clinical Pharmacy, College of Pharmacy, King Saud ...
Alkofide H, Alhammad AM, Alruwaili A, Aldemerdash A, Almangour TA, Alsuwayegh A, Almoqbel D, Albati A, Alsaud A, Enani M   +9 more
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