Results 41 to 50 of about 2,979,111 (255)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Efficacy of the Crude Root Bark Extracts of Erythrina Abyssinica on Rifampicin Resistant Mycobacterium Tuberculosis. [PDF]

, 2011
Tuberculosis (TB) is one of the leading causes of morbidity and mortality with a global mortality rate at two million deaths per year while one third of the world's population is infected with the TB bacillus.
Orodho, J.A., Bunalema, L, Bunalema, L., Kirimuhuzya, C., Orodho, J A, Tabuti, J.R., Kirimuhuzya, C, Magadula, J J, Otieno, N., Okemo, P, Otieno, N, Tabuti, JRS, Orodho, JA, Magadula, J.J., Waako, P., Tabuti, J R S, Waako, P, Magadula, JJ   +17 more
core   +1 more source

Utility of para-aminosalicylic acid in drug-resistant tuberculosis: Should it be classified as Group D3 or Group C?

Lung India, 2018
Background: The World Health Organization drug-resistant tuberculosis (DR-TB) 2016 guidelines reclassified para-aminosalicylic acid (PAS) as Group D3 “add-on” drug.
Unnati Desai, Jyotsna M Joshi
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Epidemiology of multidrug-resistant, extensively drug resistant, and totally drug resistant tuberculosis in Middle East countries

International Journal of Mycobacteriology, 2016
The 2015 represent the deadline for the global tuberculosis (TB) targets set through the Millennium Development Goals (MDG). From 2016 and onward, new goals were set to end the global TB epidemic via implementing new campaign entitled “the End TB ...
Mohanad M Ahmed, Ali A Velayati, Suhad H Mohammed   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Plasma drug activity assay for treatment optimization in tuberculosis patients [PDF]

, 2011
Item does not contain fulltextLow antituberculosis (TB) drug levels are common, but their clinical significance remains unclear, and methods of measurement are resource intensive.
Scott K. Heysell, Mpagama, S., Kibiki, Gibson S, Houpt, Eric R, Mwaigwisya, S., Heysell, Scott K, Ndusilo, Norah, Pholwat, Suporn, Mwaigwisya, Solomon, Kibiki, G.S., Solomon Mwaigwisya, Suporn Pholwat, Jean Gratz, Mtabho, C., Aarnoutse, R.E., Stellah Mpagama, Heysell, S.K., Rob E. Aarnoutse, Charles Mtabho, Gratz, J., Mpagama, Stellah, Norah Ndusilo, Gratz, Jean, Houpt, E.R., Gibson S. Kibiki, Eric R. Houpt, Mtabho, Charles, Aarnoutse, Rob E, Ndusilo, N., Pholwat, S.   +29 more
core   +1 more source

Drug-Resistant Tuberculosis and HIV Infection: Current Perspectives

HIV/AIDS: Research and Palliative Care, 2020
Abhijeet Singh, 1 Rajendra Prasad, 1, 2 Viswesvaran Balasubramanian, 1 Nikhil Gupta 3 1Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, New Delhi, Delhi 110007, India; 2Department of Pulmonary Medicine, King ...
Singh A, Prasad R, Balasubramanian V, Gupta N   +3 more
doaj