Results 51 to 60 of about 323,466 (306)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Efficiency of using SNP markers in the MSTN gene in the selection of the Pushkin breed chickens

Вавиловский журнал генетики и селекции, 2020
In the poultry industry, indicators reflecting the growth rate of young stock and the exterior characteristics of chickens are important benchmarks for breeding. Traditional selection based on phenotypic evaluation is characterized by low efficiency with
N. V. Dementeva, A. B. Vakhrameev, T. A. Larkina, O. V. Mitrofanova   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A native IgE in complex with profilin provides insights into allergen recognition and cross-reactivity

Communications Biology, 2022
The crystal structures of the murine IgE antibody in complex with highly cross-reactive profilins are reported, and the data of cross-reactivity among allergen mutants with antibodies may prove helpful for research applications in allergy therapeutics.
Benjamín García-Ramírez, Israel Mares-Mejía, Annia Rodríguez-Hernández, Patricia Cano-Sánchez, Alfredo Torres-Larios, Enrique Ortega, Adela Rodríguez-Romero   +6 more
doaj   +1 more source

A percepção dos controles internos pelos colaboradores de uma empresa de comércio exterior no estado de Santa Catarina. 2008 [PDF]

, 2008
TCC (Graduação) - Universidade Federal de Santa Catarina. Centro Socioeconômico. Curso de Ciências ContábeisEsta pesquisa teve como objetivo identificar a existência de um sistema de controle interno no setor de importação, de uma empresa operante em ...
Teodoro, Maura Regina
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Política Exterior Argentina y Medios

, 2021
El presente libro se constituye como uno de los corolarios del Proyecto de Investigación y Desarrollo (PID) denominado: “La construcción de representaciones mediáticas de la Política Exterior Argentina a través de los medios de comunicación gráfica: el ...
Fernandez Alonso, José, Bueno, María del Pilar   +1 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

INTERBREED AND INTRABREED VARIABILITY IN RABBITS AND ITS ROLE IN BREEDING

Вавиловский журнал генетики и селекции, 2014
Interbreed and intrabreed variability in basic measurements and body indices was studied in rabbits of the eight most widespread breeds. Three blockiness types were recognized: narrow-bodied, intermediate, and wide-bodied.
N. A. Balakirev, R. M. Nigmatullin
doaj  

En busca de inteligencia estratégica: cuatro factores para el nacimiento y evolución de una inteligencia civil colombiana

Ciencia Política, 2018
El artículo presenta un avance parcial de los factores claves de la teoría del nuevo institucionalismo con la aplicación de cuatro factores planteados por Amy Zegart: los grupos de interés, el tipo de trabajo secreto de la inteligencia, los asuntos ...
Álvaro José Venegas
doaj   +1 more source