Results 61 to 70 of about 429,469 (300)

A native IgE in complex with profilin provides insights into allergen recognition and cross-reactivity

open access: yesCommunications Biology, 2022
The crystal structures of the murine IgE antibody in complex with highly cross-reactive profilins are reported, and the data of cross-reactivity among allergen mutants with antibodies may prove helpful for research applications in allergy therapeutics.
Benjamín García-Ramírez   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

En busca de inteligencia estratégica: cuatro factores para el nacimiento y evolución de una inteligencia civil colombiana

open access: yesCiencia Política, 2018
El artículo presenta un avance parcial de los factores claves de la teoría del nuevo institucionalismo con la aplicación de cuatro factores planteados por Amy Zegart: los grupos de interés, el tipo de trabajo secreto de la inteligencia, los asuntos ...
Álvaro José Venegas
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

A percepção dos controles internos pelos colaboradores de uma empresa de comércio exterior no estado de Santa Catarina. 2008 [PDF]

open access: yes, 2008
TCC (Graduação) - Universidade Federal de Santa Catarina. Centro Socioeconômico. Curso de Ciências ContábeisEsta pesquisa teve como objetivo identificar a existência de um sistema de controle interno no setor de importação, de uma empresa operante em ...
Teodoro, Maura Regina
core  

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

ANÁLISE GRAVITACIONAL DO COMÉRCIO EXTERIOR DE SANTA CATARINA EM 2013 [PDF]

open access: yes, 2015
TCC (graduação) - Universidade Federal de Santa Catarina. Centro Sócio-Econômico. Relações Internacionais.O presente trabalho analisa a relação entre o fluxo de comércio exterior existente entre Santa Catarina e os cinquenta principais parceiros ...
Andrade, Daniela de
core  

Política Exterior Argentina y Medios

open access: yes, 2021
El presente libro se constituye como uno de los corolarios del Proyecto de Investigación y Desarrollo (PID) denominado: “La construcción de representaciones mediáticas de la Política Exterior Argentina a través de los medios de comunicación gráfica: el ...
Fernandez Alonso, José   +1 more
core   +1 more source

Characteristics of the brood stock of Nesvych intrabreed type of Ukrainian framed and scaly breeds of carp based on the complex of productive and reproductive parameters

open access: yesRibogospodarsʹka Nauka Ukraïni
Purpose. To provide an assessment of the complex of productive and reproductive parameters of the brood stock of the Nesvych intrabreed type of Ukrainian framed and scaly breeds of carp grown in pond conditions of the Polissia zone. Methodology.
H. Kurinenko   +6 more
doaj   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

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