Results 81 to 90 of about 323,466 (306)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Assessing Stereo Camera Applicability for Digital Monitoring of Cattle Exterior

open access: yesСельскохозяйственные машины и технологии
The paper highlights the substantial potential for digitalization in animal husbandry. Current applications of digital technologies include replacing manual data collection on animal phenotypes, particularly linear measurements of physical traits.
S. S. Yurochka   +4 more
doaj   +1 more source

Modelo probabilístico de pronostico por punto

open access: yesGeofísica Internacional, 1986
Tratamos un modelo en estrategia secuencial adaptiva, con estadística Bayesiana y función de costos de mínimo cuadrado. Se utilizan los datos de isohipsas de a lo más diez días en secuencia y se pronostica el valor que tomará la isohipsa exactamente ...
T. Castro, L. le Moyne, E. Villanueva
doaj   +1 more source

The exterior plateau problem

open access: yesMathematische Zeitschrift, 1990
For each \(r>0\), let \(D_ r\) denote the closed disc of radius r in \({\mathbb{R}}^ 2\). Let \(\Gamma \subset {\mathbb{R}}^ 3\) be a closed rectifiable Jordan curve. Let e be a unit vector in \({\mathbb{R}}^ 3\) and \(\pi_ 0\) the plane normal to e. The main result of this paper is that there exists a conformal minimal immersion u: \(\overset \circ D_
Tomi, Friedrich, Ye, Rugang
openaire   +1 more source

Detection and emotional evaluation of an electric vehicle’s exterior sound in a simulated environment [PDF]

open access: yes, 2013
Electric vehicles are quiet at low speeds and thus potentially pose a threat to pedestrians’ safety. Laws are formulating worldwide that mandate these vehicles emit sounds to alert the pedestrians of the vehicles’ approach.
Jennings, Paul A   +4 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Predicción del campo de las isohipsas, a partir de la solución de una ecuación tipo elíptica por serie de Fourier

open access: yesGeofísica Internacional, 1985
Se expresa la función de corriente como una doble serie de Fourier, en una ecuación de tipo elíptica, y se transforma en un conjunto de ecuaciones lineales para los coeficientes.
T. Castro   +2 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

O comércio exterior das Mesorregiões Catarinenses de 2000 a 2010. [PDF]

open access: yes, 2012
TCC (graduação)- Universidade Federal de Santa Catarina,Centro Sócio-Econômico, Curso de Ciências Econômicas.O presente trabalho busca descrever e analisar as mudanças ocorridas no perfil do comércio exterior das mesorregiões catarinenses de 2000 a 2010,
Marcos, Jadna Sonia
core  

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