Results 71 to 80 of about 323,466 (306)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Characteristics of the brood stock of Nesvych intrabreed type of Ukrainian framed and scaly breeds of carp based on the complex of productive and reproductive parameters

Ribogospodarsʹka Nauka Ukraïni
Purpose. To provide an assessment of the complex of productive and reproductive parameters of the brood stock of the Nesvych intrabreed type of Ukrainian framed and scaly breeds of carp grown in pond conditions of the Polissia zone. Methodology.
H. Kurinenko, Yu. Chernyk, U. Kuts, I. Hrystyniak, S. Yurchak, L. Bobeliak, V. Bekh   +6 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Exterior depth and exterior generic annihilator numbers

, 2009
We study the exterior depth of an $E$-module and its exterior generic annihilator numbers. For the exterior depth of a squarefree $E$-module we show how it relates to the symmetric depth of the corresponding $S$-module and classify those simplicial complexes having a particular exterior depth in terms of their exterior shifting.
Kaempf, Gesa, Kubitzke, Martina
openaire   +2 more sources

Política exterior y medio ambiente

, 2019
El programa de Investigación de Política Exterior Colombiana (PIPEC) es un proyecto que ha venido creciendo y consolidándose desde 2016 por estudiantes de pregrado y maestría de distintas universidades nacionales e internacionales.

core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Cuestionamientos al binario interiorexterior en el contexto de la guerra entre Israel e Irán

Tabula Rasa: Revista de Humanidades
Por lo general se asume que la geopolítica global se basa en antipatías entre Estados u otras unidades políticas, como los imperios, basados en la competencia expansionista por recursos o territorio.
John Agnew
doaj   +1 more source

Comercio exterior y transporte

, 2018
Objeto de aprendizaje: presentación multimediaEste recurso educativo permite identificar las semejanzas y diferencias conceptuales de términos como comercio internacional y exterior, modo y medio de transporte, transporte multimodal, intermodal y ...
Edgar José Pisciotti León, Pisciotti León, Edgar José   +1 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A Topology of Everyday Constellations de Georges Teyssot

Cuadernos de Proyectos Arquitectónicos, 2019
Resumen En el libro, A topology of everyday constellations, Georges Teyssot expone los temas que va persiguiendo hace décadas, manteniendo su ya conocido registro erudito y denso. Como un flâneur intenta desentrañar la espesura compleja de las tramas de
Ana Sofía Pereira
doaj