Results 101 to 110 of about 2,620,097 (300)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Estratégias de intervenção na morbidade por causas externas: como atuam agentes comunitários de saúde?

Saúde e Sociedade
As Causas Externas (CEs) de morbimortalidade têm sido um problema de saúde pública de grande magnitude no país. Buscou-se conhecer as estratégias e compreender como atuam os Agentes Comunitários de Saúde (ACSs) nesse tipo de morbidade, a partir de ...
Giceli Imperatori, Marta Julia Marques Lopes   +1 more
doaj  

Overview of the mortality from external causes of reproductive-age women in Brazil. [PDF]

Medicine (Baltimore), 2022
de Souza AMG, Costa KTDS, de Morais TNB, de Andrade FB.   +3 more
europepmc   +1 more source

An (in)efficiency based measurement of economic resilience [PDF]

The ecosystem and the economic subsystem are interlinked. In fact, it is the overconsumption of scarce resources or the overproduction of bad outputs at economic system level that causes a great part of the imbalances at the ecosystem level.
Lauwers, Ludwig H., Mondelaers, Koen
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Adequacy of Data on Injuries\' External Causes for Coding Based on ICD-10 in Inpatient Medical Records and Emergency Wards of Shahid Beheshti Hospital In Kashan

پیاورد سلامت, 2011
Background and Aim: Knowledge about the external causes of accidents is vital for their prevention, and insufficient data on external causes can reduce their usefulness. That is why, the adequacy of the sources of data is of great importance.
Mohammad Reza Rezayi Mofrad, Fatemeh Rangraz Jeddi, Maryam Rangraz Jeddi   +2 more
doaj  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Causes of adult deaths in developing countries : a review of data and methods [PDF]

Relatively little attention has been paid to the problem of premature adult mortality in developing countries, despite high levels of mortality in many countries - and despite the potentially severe social and economic consequences of adult deaths ...
Hayes, Richard, Lockett, Geraldine, Mertens, Thierry, Rodrigues, Laura   +3 more
core  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Differences in clinical characteristics of cervical spine injuries in older adults by external causes: a multicenter study of 1512 cases. [PDF]

Sci Rep, 2022
Yokogawa N, Kato S, Sasagawa T, Hayashi H, Tsuchiya H, Ando K, Nakashima H, Segi N, Funayama T, Eto F, Yamaji A, Nori S, Yamane J, Furuya T, Yunde A, Nakajima H, Yamada T, Hasegawa T, Terashima Y, Hirota R, Suzuki H, Imajo Y, Ikegami S, Uehara M, Tonomura H, Sakata M, Hashimoto K, Onoda Y, Kawaguchi K, Haruta Y, Suzuki N, Kato K, Uei H, Sawada H, Nakanishi K, Misaki K, Terai H, Tamai K, Shirasawa E, Inoue G, Kakutani K, Kakiuchi Y, Kiyasu K, Tominaga H, Tokumoto H, Iizuka Y, Takasawa E, Akeda K, Takegami N, Funao H, Oshima Y, Kaito T, Sakai D, Yoshii T, Ohba T, Otsuki B, Seki S, Miyazaki M, Ishihara M, Okada S, Imagama S, Watanabe K.   +61 more
europepmc   +1 more source