Results 71 to 80 of about 2,105,298 (255)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
The shortwave to longwave ratio in contrail radiative forcing as evident in two radiation schemes used for global GCMs [PDF]
, 2013 Contrail radiative forcing is difficult to obtain, even if contrail parameters like coverage, ice water content, crystal size etc. are known. Respective results as documented in literature hint to a substantial uncertainty.
Bock, Lisa +3 more
core
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Simulations of the last Millennium using a comprehensive climate model: The impact of the external forcing on the climate [PDF]
, 2010 The Earth’s climate continuously varies under the influence of internal processes and external factors, which are generally referred to as external forcing.
Hofer, Dominik
core
, 2018 A Here we illustrate the interplay between high frequency forcing and a transient stimulus outside the bistable regime. In the absence of oscillations, a 40ms long stimulus with amplitude 6.8 (bar) does not produce sustained activity in the model system,
Alex Roxin (272198) +3 more
core +1 more source
External forcing of the early 20th century Arctic warming
Tellus: Series A, Dynamic Meteorology and Oceanography, 2013 The observed Arctic warming during the early 20th century was comparable to present-day warming in terms of magnitude. The causes and mechanisms for the early 20th century Arctic warming are less clear and need to be better understood when considering ...
Lingling Suo +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Multidecadal Variations in the Tropical Western Pacific Driven by Externally‐Forced AMV‐Like Changes
Geophysical Research LettersMultidecadal sea surface temperature (SST) variations in the tropical western Pacific (TWP) have been attributed to nonlinear external forcing and remote influences from the Atlantic Multidecadal Variability (AMV).
Minhua Qin +3 more
doaj +1 more source
Enhanced Global Monsoon in Present Warm Period Due to Natural and Anthropogenic Forcings
Atmosphere, 2018 In this study, we investigate global monsoon precipitation (GMP) changes between the Present Warm Period (PWP, 1900–2000) and the Little Ice Age (LIA, 1250–1850) by performing millennium sensitivity simulations using the Community Earth System Model ...
Jing Chai +3 more
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source