Results 51 to 60 of about 304,985 (264)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Validation of the metabolic power model during three intermittent running-based exercises with emphasis on aerobic and anaerobic energy supply

Frontiers in Sports and Active Living
IntroductionIn intermittent sports, available internal load measurements like capillary blood techniques and portable respiratory gas analyzers are considered as gold standards in controlled laboratory environments, but are impractical for daily use in ...
Joana Brochhagen, Joana Brochhagen, Matthias W. Hoppe   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Effect of Intraset Rest Periods on External and Internal Load During Small-Sided Games in Soccer

Sports
The purpose of this study was to compare the internal and external load in continuous and intermittent small-sided games (SSG) formats. Eight semi-professional soccer players participated in the study, and they completed three protocols: (a) I ...
Ioannis Ispirlidis, Dimitrios Pantazis, Athanasios Poulios, Alexandra Avloniti, Theodoros Stampoulis, Yiannis Michailidis, Konstantinos Troupkos, Evangelos Evangelou, Dimitrios Draganidis, Dimitrios Balampanos, Nikolaos-Orestis Retzepis, Maria Protopapa, Nikolaos Mantzouranis, Nikolaos Zaras, Maria Michalopoulou, Ioannis G. Fatouros, Athanasios Chatzinikolaou   +16 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modelling Energy Demands of Cross-Country Tests in 2-Star to 5-Star Eventing Competitions

Animals
Eventing is an Olympic equestrian discipline comprising dressage, cross-country, and show jumping, with the cross-country phase imposing the greatest physical demands on horses.
Anna M. Liedtke, Hans Meijer, Stephanie Horstmann, Caroline von Reitzenstein, Insa Rump, Katharina Kirsch   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

STEADY STATES OF THE HINGED EXTENSIBLE BEAM WITH EXTERNAL LOAD [PDF]

Mathematical Models and Methods in Applied Sciences, 2010
We analyze from both the physical and the analytical viewpoints the equation [Formula: see text] the solutions represent the equilibria of a thin extensible beam subject to external load.
M. Coti Zelati, C. Giorgi, PATA, VITTORINO   +2 more
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Comparing Average and Peak Physical Demands and Well-Being Status During Basketball Back-to-Back Games

Applied Sciences
This study investigated the impact of consecutive basketball games on the physical demands and well-being of young players under 18 years old (U-18), focusing on the peak demands (PD).
Franc García, Jordi Vicens-Bordas, Javier Espasa-Labrador, Javier Peña, Julio Calleja-González   +4 more
doaj   +1 more source