Results 71 to 80 of about 1,262,881 (342)

Mathematical Modelling of Different Types of Body Support Surface for Pressure Ulcer Prevention [PDF]

, 2014
Pressure ulcer is a common problem for today’s healthcare industry. It occurs due to external load applied to the skin. Also when the subject is immobile for a longer period of time and there is continuous load applied to a particular area of human body,
Cole, Jonathan, Dubey, Venketesh N., Hickish, Tamas F., Mishu, Mahbub C.   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Uncovering the Latent Components of Physical Performance in Professional Soccer: Evidence from the Turkish First Division

Journal of Functional Morphology and Kinesiology
Background: Physical performance in soccer is usually described through isolated indicators such as total distance or sprint frequency, which may overlook the broader structure of match demands. Purpose: This study aimed to identify the latent components
Spyridon Plakias, Dimitris Tsaopoulos, Themistoklis Tsatalas, Giannis Giakas   +3 more
doaj   +1 more source

Training load monitoring by position and task in professional men´s basketball

E-balonmano.com: Revista de Ciencias del Deporte, 2021
The aim of this study was to analyze the training load of the different tasks of a professional basketball team, based on the tasks and player positions. A total of 10 professional basketball players participated (Mage = 23.70; SD = 2.26) who carried out
José Carlos Ponce Bordón, Iván Ramírez Bravo, Miguel Ángel López Gajardo, Jesús Díaz García   +3 more
doaj  

In-season internal and external training load quantification of an elite European soccer team [PDF]

, 2019
Elite soccer teams that participate in European competitions need to have players in the best physical and psychological status possible to play matches.
Brito, João, Ferraz, Ricardo, Marinho, Daniel A., Marques, Mário C., Martins, Alexandre, Mendes, Bruno, Oliveira, Rafael   +6 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Mechanical Casing Confining Pressure Simulation Method

Shiyou jixie, 2017
The casing confining pressure is usually applied to the casing by hydraulic pressure, which can only provide uniform load and cannot simulate the non-uniform load of the formation due to the characteristics of the liquid. To address the issue, a new test
Xu Bihua, Zhang Biao, Xie Yingquan, Tang Wei, Tan Yuanming   +4 more
doaj  

Analysis of externally loaded bolted joints : analytical, computational and experimental study [PDF]

, 2009
The behaviour of a simple single-bolted-joint under tensile separating loads is analysed using conventional analytical methods, a finite element approach and experimental techniques.
Anley, R.E., Gray, T.G.F., Nash, D.H., Williams, J.G.   +3 more
core   +1 more source