Results 61 to 70 of about 313,784 (306)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Initial subjective load carriage injury data collected by interviews and questionnaires [PDF]

, 2007
This study aimed to identify the types, incidence, and causes of any potential load carriage injuries or discomfort as a result of a 2-hour, forced-speed, treadmill march carrying 20 kg.
Birrell, Stewart A., Hooper, Robin H.
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Stability of Manipulator Configuration Under External Loading [PDF]

Volume 3: Advanced Composite Materials and Processing; Robotics; Information Management and PLM; Design Engineering, 2012
The paper is devoted to the analysis of robotic manipulator behavior under internal and external loadings. The main contributions are in the area of stability analysis of manipulator configurations corresponding to the loaded static equilibrium. In contrast to other works, in addition to usually studied the end-platform behavior with respect to the ...
Klimchik, Alexandr, Pashkevich, Anatol, Chablat, Damien   +2 more
openaire   +2 more sources

The effects of defensive style and final game outcome on the external training load of professional basketball players

, 2020
This study aimed to analyse the influence of different contextual factors (i.e., defensive style and game outcome) on basketball players’ external load during games-based drills using ultrawideband (UWB) technology.
Javier Raya-González, Castillo, Daniel,, Raya-Gonzalez, Javier,, Clemente, Filipe Manuel,, Daniele Conte, Alejandro Rodríguez-Fernández, Rodriguez-Fernandez, Alejandro,, Daniel Castillo, Filipe Clemente, Conte, Daniele,   +9 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Relationships between External, Wearable Sensor-Based, and Internal Parameters: A Systematic Review

Sensors, 2023
Micro electro-mechanical systems (MEMS) are used to record training and match play of intermittent team sport athletes. Paired with estimates of internal responses or adaptations to exercise, practitioners gain insight into players’ dose–response ...
Janina Helwig, Janik Diels, Mareike Röll, Hubert Mahler, Albert Gollhofer, Kai Roecker, Steffen Willwacher   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Uncovering the Latent Components of Physical Performance in Professional Soccer: Evidence from the Turkish First Division

Journal of Functional Morphology and Kinesiology
Background: Physical performance in soccer is usually described through isolated indicators such as total distance or sprint frequency, which may overlook the broader structure of match demands. Purpose: This study aimed to identify the latent components
Spyridon Plakias, Dimitris Tsaopoulos, Themistoklis Tsatalas, Giannis Giakas   +3 more
doaj   +1 more source

Training load monitoring by position and task in professional men´s basketball

E-balonmano.com: Revista de Ciencias del Deporte, 2021
The aim of this study was to analyze the training load of the different tasks of a professional basketball team, based on the tasks and player positions. A total of 10 professional basketball players participated (Mage = 23.70; SD = 2.26) who carried out
José Carlos Ponce Bordón, Iván Ramírez Bravo, Miguel Ángel López Gajardo, Jesús Díaz García   +3 more
doaj