Results 61 to 70 of about 304,985 (264)

Quasistatic modeling of concentric tube robots with external loads [PDF]

2010 IEEE/RSJ International Conference on Intelligent Robots and Systems, 2010
Concentric tube robots are a subset of continuum robots constructed by combining pre-curved elastic tubes. As the tubes are rotated and translated with respect to each other, their curvatures interact elastically, enabling control of the robot's tip configuration as well as the curvature along its length.
Jesse Lock, Genevieve Laing, Mohsen Mahvash, Pierre E. Dupont   +3 more
openaire   +5 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A Mechanical Casing Confining Pressure Simulation Method

Shiyou jixie, 2017
The casing confining pressure is usually applied to the casing by hydraulic pressure, which can only provide uniform load and cannot simulate the non-uniform load of the formation due to the characteristics of the liquid. To address the issue, a new test
Xu Bihua, Zhang Biao, Xie Yingquan, Tang Wei, Tan Yuanming   +4 more
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Relationship between Physical Demands and Player Performance in Professional Female Basketball Players Using Inertial Movement Units

Sensors
Load monitoring has been identified as a valuable tool for optimizing training planning and minimizing injury risk. This study’s aim was divided into two main objectives: (1) to describe the physical demands during official competition through IMU ...
Javier Espasa-Labrador, Carlos Martínez-Rubio, José María Oliva-Lozano, Julio Calleja-González, Marta Carrasco-Marginet, Azahara Fort-Vanmeerhaeghe   +5 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The puzzle of monitoring training load in winter sports - A hard nut to crack?

Current Issues in Sport Science
Elite winter sports have become increasingly professionalized and commercialized, often accompanied by congested competition schedules. This has brought the topic of load management, i.e., planning, monitoring, and adaptation, enormous attention in the ...
Nils Haller, Tilmann Strepp, Thomas Stöggl   +2 more
doaj   +1 more source