Results 101 to 110 of about 3,111,277 (372)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Is the proton radius puzzle evidence of extra dimensions? [PDF]
, 2015 The proton charge radius inferred from muonic hydrogen spectroscopy is not compatible with the previous value given by CODATA-2010, which, on its turn, essentially relies on measurements of the electron–proton interaction.
F. Dahia, A. S. Lemos
semanticscholar +1 more source
Large hierarchy from extra dimensions [PDF]
Physics Letters B, 2000 We argue that the familiar gauge hierarchy between the fundamental Planck scale M_{Pl} and the electroweak scale M_{W}, can be naturally explained in higher dimensional theories with relatively large radii (R_c > 1/M_{Pl}) extra dimensions. In particular, we show that it is possible that the electroweak Higgs mass at high energies is of the order of
Chaichian, Masud, Kobakhidze, Archil B.
openaire +3 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Hidden symmetries from extra dimensions
Journal of High Energy PhysicsIn Kaluza-Klein compactifications, some symmetries of the higher dimensional theory are preserved in lower dimensions, others are broken, and occasionally, there are symmetry enhancements.
Marco Ciafardini +3 more
doaj +1 more source
Reconsidering extra time-like dimensions
, 2006 In this study we reconsider the phenomenological problems related to tachyonic modes in the context of extra time-like dimensions. First we reconsider a lower bound on the size of extra time-like dimensions.
Erdem, Recai, Un, Cem S.
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Proof of dispersion relations for the amplitude in theories with a compactified space dimension
Journal of High Energy Physics, 2020 The analyticity properties of the scattering amplitude in the nonforward direction are investigated for a field theory in the manifold R 3,1 ⨂ S 1.
Jnanadeva Maharana
doaj +1 more source
Optical activity from extra dimensions [PDF]
Physical Review D, 2003 Four ...
Ganguly, Avijit K., Parthasarathy, R.
openaire +2 more sources
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source