Results 31 to 40 of about 113,079 (217)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analysis of inflationary models in higher-dimensional uniform inflation

Journal of High Energy Physics
We consider higher-dimensional uniform inflation, in which the extra dimensions expand at the same rate as three-dimensional non-compact space during inflation.
Takuya Hirose
doaj   +1 more source

Dark energy, extra dimensions, and the Swampland

Journal of High Energy Physics, 2020
Perhaps the greatest challenge for fundamental theories based on compactification from extra dimensions is accommodating a period of accelerated cosmological expansion.
Gabriele Montefalcone, Paul J. Steinhardt, Daniel H. Wesley   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Dark dimension right-handed neutrinos confronted with long-baseline oscillation experiments

Journal of High Energy Physics
Right-handed neutrinos are naturally induced by dark extra dimension models and play an essential role in neutrino oscillations. The model parameters can be examined by the long-baseline neutrino oscillation experiments.
Ai-Yu Bai, Auttakit Chatrabhuti, Yin-Yuan Huang, Hiroshi Isono, Jian Tang   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Non-trivial thick brane realisations with 3-forms

Journal of High Energy Physics
We explore the construction of four-dimensional thick branes supported by massless 3-forms in a five-dimensional bulk space. The required residual Poincaré symmetry on the brane is realised as a combination of the bulk symmetries and the internal gauge ...
Bruno J. Barros, Jose Beltrán Jiménez
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Searching for a dark dimension right-handed neutrino in KATRIN

Journal of High Energy Physics
We study the possibility that the Right-handed neutrino is a five-dimensional state propagating along a micron size extra dimension, as required in the dark dimension proposal.
Ignatios Antoniadis, Auttakit Chatrabhuti, Hiroshi Isono   +2 more
doaj   +1 more source

Flavour physics and extra-dimensions

EPJ Web of Conferences, 2018
Randall-Sundrum (RS) model of warped extra-dimensions were originally proposed to explain the Planck-weak scale hierarchy. It was soon realised that modifications of the original setup, by introducing the fields in the bulk, has several interesting ...
Iyer Abhishek M.
doaj   +1 more source