Extracellular mechanotransduction [PDF]
Journal of General Physiology, 2022 We highlight the force-sensing function of extracellular matrix and present a complementary mechanotransduction paradigm.
Haller, Stephen J., Dudley, Andrew T.
openaire +3 more sources
Extracellular Vesicles as Regulators of the Extracellular Matrix
Bioengineering, 2023 Extracellular vesicles (EVs) are small membrane-bound vesicles secreted into the extracellular space by all cell types. EVs transfer their cargo which includes nucleic acids, proteins, and lipids to facilitate cell-to-cell communication. As EVs are released and move from parent to recipient cell, EVs interact with the extracellular matrix (ECM) which ...
Neil J. Patel +2 more
openaire +3 more sources
Extracellular respiration [PDF]
Molecular Microbiology, 2007 SummaryAlthough it has long been known that microbes can generate energy using diverse strategies, only recently has it become clear that a growing number involve electron transfer to or from extracellular substrates. The best‐known example of what we will term ‘extracellular respiration’ is electron transfer between microbes and minerals, such as iron
Gralnick, Jeffrey A., Newman, Dianne K.
openaire +3 more sources
Extracellular signals regulate the biogenesis of extracellular vesicles
Biological Research, 2022 AbstractExtracellular vesicles (EVs) are naturally released membrane vesicles that act as carriers of proteins and RNAs for intercellular communication. With various biomolecules and specific ligands, EV has represented a novel form of information transfer, which possesses extremely outstanding efficiency and specificity compared to the classical ...
Yong Jin +5 more
openaire +3 more sources
Identification of a novel zinc metalloprotease through a global analysis of clostridium difficile extracellular proteins [PDF]
, 2013 Clostridium difficile is a major cause of infectious diarrhea worldwide. Although the cell surface proteins are recognized to be important in clostridial pathogenesis, biological functions of only a few are known.
A Barketi-Klai +73 more
core +7 more sources
Lactate-proton co-transport and its contribution to interstitial acidification during hypoxia in isolated rat spinal roots [PDF]
, 1993 Exposure of nervous tissue to hypoxia results in interstitial acidification. There is evidence for concomitant decrease in extracellular pH to the increase in tissue lactate.
Aronson +45 more
core +1 more source
FEBS Letters, 1990 A succinct overview of recent results on the biochemistry of extracellular matrix (ECM) is presented. The rapid expansion of this discipline over the best decades renders impossible to give an even approximately complete coverage of matrix biology. Some selected results concerning the four major families of macromolecules composing the ECM, that is ...
Labat-Robert, J. +2 more
openaire +2 more sources
A crucial sequence for transglutaminase type 2 extracellular trafficking in renal tubular epithelial cells lies in its N-terminal {beta}-sandwich domain [PDF]
, 2011 Transglutaminase type 2 (TG2) catalyzes the formation of an -( -glutamyl)-lysine isopeptide bond between adjacent peptides or proteins including those of the extracellular matrix (ECM).
Chou, CY +5 more
core +1 more source
mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]
, 2018 Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua +9 more
core +2 more sources
Mechanical and Systems Biology of Cancer [PDF]
, 2018 Mechanics and biochemical signaling are both often deregulated in cancer, leading to cancer cell phenotypes that exhibit increased invasiveness, proliferation, and survival.
Bakal, Chris +2 more
core +3 more sources