Results 1 to 10 of about 1,944,741 (224)

Targeting extracellular Hsp90: A unique frontier against cancer

Frontiers in Molecular Biosciences, 2022
The molecular chaperone Heat Shock Protein-90 (Hsp90) is known to interact with over 300 client proteins as well as regulatory factors (eg. nucleotide and proteins) that facilitate execution of its role as a chaperone and, ultimately, client protein ...
Rebecca A. Sager, Rebecca A. Sager, Farzana Khan, Farzana Khan, Lorenzo Toneatto, Lorenzo Toneatto, Lorenzo Toneatto, SarahBeth D. Votra, Sarah J. Backe, Sarah J. Backe, Sarah J. Backe, Mark R. Woodford, Mark R. Woodford, Mark R. Woodford, Mehdi Mollapour, Mehdi Mollapour, Mehdi Mollapour, Dimitra Bourboulia, Dimitra Bourboulia, Dimitra Bourboulia   +19 more
doaj   +1 more source

Extracellular Vesicles in neural cell interaction and CNS homeostasis

FASEB BioAdvances, 2021
Central nervous system (CNS) homeostasis critically depends on the interaction between neurons and glia cells. Extracellular vesicles (EVs) recently emerged as versatile messengers in CNS cell communication.
Andrea Schnatz, Christina Müller, Alexandra Brahmer, Eva‐Maria Krämer‐Albers   +3 more
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A Triple High Throughput Screening for Extracellular Vesicle Inducing Agents With Immunostimulatory Activity

Frontiers in Pharmacology, 2022
Extracellular vesicles (EVs) play an important role in intercellular communication and regulation of cells, especially in the immune system where EVs can participate in antigen presentation and may have adjuvant effects.
Nikunj M. Shukla, Fumi Sato-Kaneko, Shiyin Yao, Minya Pu, Michael Chan, Fitzgerald S. Lao, Yukiya Sako, Tetsuya Saito, Tetsuya Saito, Karen Messer, Tomoko Hayashi, Howard B. Cottam, Maripat Corr, Dennis A. Carson   +13 more
doaj   +1 more source

Reduction in Glomerular and Renal Tubular Damage in Kidneys of Diabetic Rats Supplemented with Alpha-Lipoic Acid

Acta Veterinaria, 2022
Chronic hyperglycemia caused by diabetes results in systemic damage to the body, and the kidney ends up being the target of tissue damage. The use of antioxidants such as alpha-lipoic acid (ALA) has been shown to improve clinical and biochemical ...
Fraga Tamyris Pontes, Corrêa Lanna Beatriz Neves Silva, Taboas Julia Galian Ribeiro, Da Silva Vivian Alves Pereira, Boaventura Gilson Teles, Chagas Mauricio Alves   +5 more
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The Role of Extracellular Vesicles in Osteoporosis: A Scoping Review

Membranes, 2022
As an insidious metabolic bone disease, osteoporosis plagues the world, with high incidence rates. Patients with osteoporosis are prone to falls and becoming disabled, and their cone fractures and hip fractures are very serious, so the diagnosis and ...
Weifei Zhang, Pengzhou Huang, Jianjing Lin, Hui Zeng   +3 more
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Extracellular Proteome Analysis Shows the Abundance of Histidine Kinase Sensor Protein, DNA Helicase, Putative Lipoprotein Containing Peptidase M75 Domain and Peptidase C39 Domain Protein in Leptospira interrogans Grown in EMJH Medium

Pathogens, 2021
Leptospirosis is a re-emerging form of zoonosis that is caused by the spirochete pathogen Leptospira. Extracellular proteins play critical roles in the pathogenicity and survival of this pathogen in the host and environment.
Abhijit Sarma, Dhandapani Gunasekaran, Devasahayam Arokia Balaya Rex, Thoduvayil Sikha, Homen Phukan, Kumar Mangalaparthi Kiran, Sneha M. Pinto, Thottethodi Subrahmanya Keshava Prasad, Madathiparambil G. Madanan   +8 more
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Investigating the consistency of extracellular vesicle production from breast cancer subtypes using CELLine adherent bioreactors

Journal of Extracellular Biology, 2022
Extracellular vesicle (EV) research has grown rapidly in recent years, largely due to the potential use of EVs as liquid biopsy biomarkers or therapeutics.
Colin L. Hisey, Anastasiia Artuyants, George Guo, Vanessa Chang, Gabrielle Reshef, Martin Middleditch, Bincy Jacob, Lawrence W. Chamley, Cherie Blenkiron   +8 more
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Improving of pelB-Secreted MPT64 protein released by Escherichia coli BL21 (DE3) using Triton X-100 and Tween-80

Journal of Advanced Pharmaceutical Technology & Research, 2022
pelB has been known as a successful signal peptide to translocate the protein target extracellularly in the Escherichia coli system. However, in our previous study, the yield of MPT64 protein extracellular recovery was still low and plenty of this ...
Sri Agung Fitri Kusuma, Toto Subroto, Ida Parwati, Yaya Rukayadi, Muhammad Fadhlillah, Ruth Michellee Pardede, Alif Virisy Berlian, Gina Sabila   +7 more
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Thiol Modifications in the Extracellular Space—Key Proteins in Inflammation and Viral Infection

Frontiers in Immunology, 2022
Posttranslational modifications (PTMs) allow to control molecular and cellular functions in response to specific signals and changes in the microenvironment of cells. They regulate structure, localization, stability, and function of proteins in a spatial
Kathrin A. Brücksken, Paola Loreto Palacio, Eva-Maria Hanschmann   +2 more
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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Journal of Extracellular Vesicles, 2018
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures ...
C. Théry, K. Witwer, E. Aikawa, M. Alcaraz, Johnathon D. Anderson, R. Andriantsitohaina, A. Antoniou, T. Arab, F. Archer, Georgia K. Atkin-Smith, D. Ayre, J. Bach, Daniel Bachurski, H. Baharvand, L. Balaj, S. Baldacchino, N. Bauer, A. A. Baxter, M. Bebawy, C. Beckham, Apolonija Bedina Zavec, A. Benmoussa, A. Berardi, P. Bergese, E. Bielska, C. Blenkiron, S. Bobis‐Wozowicz, É. Boilard, W. Boireau, A. Bongiovanni, F. Borràs, Steffi Bosch, C. Boulanger, X. Breakefield, Andrew M. Breglio, Meadhbh Á. Brennan, D. Brigstock, A. Brisson, M. Broekman, J. Bromberg, Paulina Bryl-Górecka, S. Buch, A. Buck, D. Burger, Sara Busatto, Dominik Buschmann, B. Bussolati, E. Buzás, James Brian Byrd, G. Camussi, David Carter, Sarah Caruso, L. Chamley, Yu-Ting Chang, Chihchen Chen, Shuai Chen, Lesley Cheng, Andrew R. Chin, A. Clayton, S. Clerici, A. Cocks, Emanuele Cocucci, R. Coffey, A. Cordeiro-da-Silva, Y. Couch, F. Coumans, B. Coyle, Rossella Crescitelli, M. F. Criado, C. D’Souza-Schorey, Saumya Das, Amrita Datta Chaudhuri, P. de Candia, E. F. de Santana, O. De Wever, H. D. del Portillo, T. Demaret, Sarah Deville, A. Devitt, Bert Dhondt, D. Di Vizio, L. Dieterich, V. Dolo, A. P. Domínguez Rubio, M. Dominici, M. R. Dourado, Tom A P Driedonks, F. V. Duarte, Heather M. Duncan, R. Eichenberger, K. Ekström, S. El Andaloussi, C. Élie-Caille, U. Erdbrügger, J. Falcón-Perez, F. Fatima, Jason E. Fish, Miguel Flores-Bellver, András I Försönits, A. Frelet-Barrand, F. Fricke, G. Fuhrmann, S. Gabrielsson, Ana Gámez-Valero, C. Gardiner, Kathrin Gärtner, R. Gaudin, Y. Gho, B. Giebel, C. Gilbert, M. Gimona, I. Giusti, D. Goberdhan, A. Görgens, S. Gorski, D. Greening, J. Gross, A. Gualerzi, G. Gupta, D. Gustafson, A. Handberg, R. Haraszti, P. Harrison, H. Hegyesi, A. Hendrix, A. Hill, F. Hochberg, K. Hoffmann, B. Holder, H. Holthofer, Baharak Hosseinkhani, Guoku Hu, Yiyao Huang, V. Huber, S. Hunt, A. Ibrahim, T. Ikezu, J. Inal, Mustafa Işın, Alena Ivanova, Hannah K. Jackson, S. Jacobsen, S. Jay, M. Jayachandran, G. Jenster, Lanzhou Jiang, Suzanne M Johnson, Jennifer C. Jones, A. Jong, T. Jovanović-Talisman, Stephanie Jung, R. Kalluri, S. Kano, S. Kaur, Yumi Kawamura, E. Keller, Delaram Khamari, E. Khomyakova, A. Khvorova, P. Kierulf, K. Kim, T. Kislinger, Mikael Klingeborn, D. Klinke, M. Kornek, Maja Kosanović, Á. Kovács, Eva-Maria Krämer-Albers, S. Krasemann, Mirja Krause, I. Kurochkin, G. Kusuma, Sören Kuypers, S. Laitinen, Scott M Langevin, L. Languino, J. Lannigan, Cecilia Lässer, L. Laurent, Grégory Lavieu, Elisa Lázaro-Ibáñez, S. Le Lay, Myung-Shin Lee, Y. Lee, Débora S. Lemos, Metka Lenassi, A. Leszczyńska, Isaac T. S. Li, K. Liao, S. Libregts, E. Ligeti, R. Lim, S. Lim, A. Linē, K. Linnemannstöns, A. Llorente, C. Lombard, M. Lorenowicz, Á. Lörincz, J. Lötvall, Jason Lovett, Michelle C. Lowry, X. Loyer, Q. Lu, B. Lukomska, T. Lunavat, Sybren L. N. Maas, H. Malhi, A. Marcilla, J. Mariani, Javier Mariscal, E. Martens-Uzunova, Lorena Martín-Jaular, M. C. Martı́nez, V. Martins, Mathilde Mathieu, S. Mathivanan, M. Maugeri, L. McGinnis, M. McVey, D. Meckes, K. Meehan, I. Mertens, Valentina R Minciacchi, A. Möller, M. Møller Jørgensen, A. Morales-Kastresana, Jess Morhayim, F. Mullier, M. Muraca, L. Musante, V. Mussack, D. Muth, K. Myburgh, T. Najrana, Muhammad Nawaz, I. Nazarenko, P. Nejsum, C. Néri, T. Neri, R. Nieuwland, L. Nimrichter, J. Nolan, E. N. Nolte-‘t Hoen, Nicole Noren Hooten, L. O’Driscoll, Tina M. O’Grady, A. O’Loghlen, T. Ochiya, M. Olivier, A. Ortiz, L. Ortiz, X. Osteikoetxea, O. Østergaard, M. Ostrowski, Jaesung Park, D. Pegtel, H. Peinado, F. Perut, M. Pfaffl, D. Phinney, Bartijn C H Pieters, R. Pink, D. Pisetsky, E. Pogge von Strandmann, Iva Polakovičová, I. Poon, B. Powell, I. Prada, L. Pulliam, P. Quesenberry, A. Radeghieri, R. Raffai, S. Raimondo, J. Rak, M. Ramirez, G. Raposo, Morsi S Rayyan, Neta Regev-Rudzki, F. Ricklefs, P. Robbins, D. Roberts, S. Rodrigues, E. Rohde, S. Rome, Kasper M A Rouschop, A. Rughetti, A. Russell, Paula Saá, S. Sahoo, E. Salas-Huenuleo, Catherine Sánchez, J. Saugstad, Meike J. Saul, R. Schiffelers, R. Schneider, T. H. Schøyen, Aaron Scott, Eriomina Shahaj, Shivani Sharma, O. Shatnyeva, Faezeh Shekari, G. Shelke, A. Shetty, K. Shiba, P. Siljander, Andreia M. Silva, Agata Skowronek, Orman L Snyder, R. Soares, Barbara W. Sódar, Carolina Soekmadji, J. Sotillo, P. Stahl, W. Stoorvogel, Shannon L. Stott, E. Strasser, S. Swift, H. Tahara, M. Tewari, Kate Timms, Swasti Tiwari, Rochelle Tixeira, M. Tkach, W. Toh, R. Tomasini, A. Torrecilhas, J. Tosar, Vasilis Toxavidis, L. Urbanelli, P. Vader, B. W. van Balkom, S. G. van der Grein, J. Van Deun, M. V. van Herwijnen, K. Van Keuren-Jensen, Guillaume van Niel, M. V. van Royen, A. V. van Wijnen, M. Vasconcelos, Ivan J. Vechetti, T. Veit, L. Vella, É. Velot, F. Verweij, B. Vestad, J. Viñas, T. Visnovitz, Krisztina V. Vukman, Jessica Wahlgren, Dionysios C. Watson, M. Wauben, Alissa M. Weaver, J. Webber, V. Weber, A. Wehman, D. Weiss, J. Welsh, Sebastian Wendt, Å. Wheelock, Z. Wiener, Leonie Witte, Joy Wolfram, A. Xagorari, P. Xander, Jing Xu, Xiaomei Yan, M. Yáñez‐Mó, Hang Yin, Y. Yuana, V. Zappulli, J. Zarubova, Vytautas Žėkas, Jian-ye Zhang, Zezhou Zhao, Lei Zheng, Alexander R Zheutlin, Antje M. Zickler, P. Zimmermann, Angela M. Zivkovic, D. Zocco, E. Zuba-Surma   +381 more
semanticscholar   +1 more source