Results 11 to 20 of about 2,493,789 (332)

Extracellular mechanotransduction [PDF]

Journal of General Physiology, 2022
We highlight the force-sensing function of extracellular matrix and present a complementary mechanotransduction paradigm.
Haller, Stephen J., Dudley, Andrew T.
openaire   +3 more sources

Extracellular Proteome Analysis Shows the Abundance of Histidine Kinase Sensor Protein, DNA Helicase, Putative Lipoprotein Containing Peptidase M75 Domain and Peptidase C39 Domain Protein in Leptospira interrogans Grown in EMJH Medium

Pathogens, 2021
Leptospirosis is a re-emerging form of zoonosis that is caused by the spirochete pathogen Leptospira. Extracellular proteins play critical roles in the pathogenicity and survival of this pathogen in the host and environment.
Abhijit Sarma, Dhandapani Gunasekaran, Devasahayam Arokia Balaya Rex, Thoduvayil Sikha, Homen Phukan, Kumar Mangalaparthi Kiran, Sneha M. Pinto, Thottethodi Subrahmanya Keshava Prasad, Madathiparambil G. Madanan   +8 more
doaj   +1 more source

Extracellular Vesicles as Regulators of the Extracellular Matrix

Bioengineering, 2023
Extracellular vesicles (EVs) are small membrane-bound vesicles secreted into the extracellular space by all cell types. EVs transfer their cargo which includes nucleic acids, proteins, and lipids to facilitate cell-to-cell communication. As EVs are released and move from parent to recipient cell, EVs interact with the extracellular matrix (ECM) which ...
Neil J. Patel, Anisa Ashraf, Eun Ji Chung   +2 more
openaire   +3 more sources

A Triple High Throughput Screening for Extracellular Vesicle Inducing Agents With Immunostimulatory Activity

Frontiers in Pharmacology, 2022
Extracellular vesicles (EVs) play an important role in intercellular communication and regulation of cells, especially in the immune system where EVs can participate in antigen presentation and may have adjuvant effects.
Nikunj M. Shukla, Fumi Sato-Kaneko, Shiyin Yao, Minya Pu, Michael Chan, Fitzgerald S. Lao, Yukiya Sako, Tetsuya Saito, Tetsuya Saito, Karen Messer, Tomoko Hayashi, Howard B. Cottam, Maripat Corr, Dennis A. Carson   +13 more
doaj   +1 more source

Identification of a novel zinc metalloprotease through a global analysis of clostridium difficile extracellular proteins [PDF]

, 2013
Clostridium difficile is a major cause of infectious diarrhea worldwide. Although the cell surface proteins are recognized to be important in clostridial pathogenesis, biological functions of only a few are known.
A Barketi-Klai, A Bateman, A Boetzkes, A Dhalluin, A Molla, A Tasteyre, A Tasteyre, A Tasteyre, A Wright, A Wright, AJ Waligora, B Singh, BR Hoffmann, C Janoir, C Schwan, CB Reynolds, CC Häse, CM Surawicz, D Lyras, D Zhang, Davide Serruto, DC Nelson, DE Voth, DJ Rigden, E Calabi, E Calabi, EJ Kuipers, F Tonello, FH Niesen, Francesca Cantini, G Bensi, GA Dalkas, GM Slynn, H Maeda, I Poilane, Jeffrey T. Rubino, JM Kirby, JR O'Connor, JW Teo, K Mukherjee, K Yokoyama, KR Klimpel, L de la Riva, L Tulli, LG Pacheco, M Cerquetti, M Desvaux, M Miura, M Monot, M Rupnik, M Sebaihia, M Warny, MA Breidenbach, Manuele Martinelli, Maria Scarselli, Massimiliano Biagini, Meera Unnikrishnan, Mikael Skurnik, MJ Rodríguez-Ortega, N Sengupta, Nathalie Norais, NM Hooper, NS Duesbery, O Schneewind, Rosanna Leuzzi, RP Fagan, S Péchiné, S Péchiné, S Ravipaty, SA Kuehne, T Karasawa, T Karjalainen, TC Dingle, Valeria Cafardi   +73 more
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Targeting extracellular Hsp90: A unique frontier against cancer

Frontiers in Molecular Biosciences, 2022
The molecular chaperone Heat Shock Protein-90 (Hsp90) is known to interact with over 300 client proteins as well as regulatory factors (eg. nucleotide and proteins) that facilitate execution of its role as a chaperone and, ultimately, client protein ...
Rebecca A. Sager, Rebecca A. Sager, Farzana Khan, Farzana Khan, Lorenzo Toneatto, Lorenzo Toneatto, Lorenzo Toneatto, SarahBeth D. Votra, Sarah J. Backe, Sarah J. Backe, Sarah J. Backe, Mark R. Woodford, Mark R. Woodford, Mark R. Woodford, Mehdi Mollapour, Mehdi Mollapour, Mehdi Mollapour, Dimitra Bourboulia, Dimitra Bourboulia, Dimitra Bourboulia   +19 more
doaj   +1 more source

The Role of Extracellular Vesicles in Osteoporosis: A Scoping Review

Membranes, 2022
As an insidious metabolic bone disease, osteoporosis plagues the world, with high incidence rates. Patients with osteoporosis are prone to falls and becoming disabled, and their cone fractures and hip fractures are very serious, so the diagnosis and ...
Weifei Zhang, Pengzhou Huang, Jianjing Lin, Hui Zeng   +3 more
doaj   +1 more source

Fragmentation of extracellular ribosomes and tRNAs shapes the extracellular RNAome [PDF]

Nucleic Acids Research, 2020
Abstract A major proportion of extracellular RNAs (exRNAs) do not copurify with extracellular vesicles (EVs) and remain in ultracentrifugation supernatants of cell-conditioned medium or mammalian blood serum. However, little is known about exRNAs beyond EVs. We have previously shown that the composition of the nonvesicular exRNA fraction
Bruno Costa, Bruno Costa, Mercedes Segovia, Tania Possi, Pavel Ivanov, Pavel Ivanov, Pavel Ivanov, Alfonso Cayota, Alfonso Cayota, Fabiana Gámbaro, Fabiana Gámbaro, Pablo Fagúndez, Pablo Fagúndez, Mauricio Castellano, Mauricio Castellano, Juan Pablo Tosar, Yasutoshi Akiyama, Yasutoshi Akiyama, Marcelo Hill, Alvaro Olivera   +19 more
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Extracellular matrix [PDF]

FEBS Letters, 1990
A succinct overview of recent results on the biochemistry of extracellular matrix (ECM) is presented. The rapid expansion of this discipline over the best decades renders impossible to give an even approximately complete coverage of matrix biology. Some selected results concerning the four major families of macromolecules composing the ECM, that is ...
Labat-Robert, J., Bihari-Varga, M., Robert, L.   +2 more
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Extracellular signals regulate the biogenesis of extracellular vesicles

Biological Research, 2022
AbstractExtracellular vesicles (EVs) are naturally released membrane vesicles that act as carriers of proteins and RNAs for intercellular communication. With various biomolecules and specific ligands, EV has represented a novel form of information transfer, which possesses extremely outstanding efficiency and specificity compared to the classical ...
Yong Jin, Lele Ma, Wanying Zhang, Wen Yang, Qiyu Feng, Hongyang Wang   +5 more
openaire   +3 more sources