Results 21 to 30 of about 1,664,773 (248)

Control of Intracellular Calcium Signaling as a Neuroprotective Strategy

Molecules, 2010
Both acute and chronic degenerative diseases of the nervous system reduce the viability and function of neurons through changes in intracellular calcium signaling.
R. Scott Duncan, Daryl L. Goad, Michael A. Grillo, Simon Kaja, Andrew J. Payne, Peter Koulen   +5 more
doaj   +1 more source

Congenital Zika Syndrome: Insights from Integrated Proteomic and Metabolomic Analysis

Biomolecules
Background: In this study, we investigated the role of extracellular vesicles (EVs) in the pathogenesis of Congenital Zika Syndrome (CZS). Previous studies have highlighted the role of EVs in intercellular communication and the modulation of biological ...
Leticia Gomes-de-Pontes, Lucila Akune Barreiros, Lillian Nunes Gomes, Ranieri Coelho Salgado, Sarah Maria da Silva Napoleão, Paulo V. Soeiro-Pereira, Saulo Duarte Passos, Antonio Condino-Neto   +7 more
doaj   +1 more source

Improving of pelB-Secreted MPT64 protein released by Escherichia coli BL21 (DE3) using Triton X-100 and Tween-80

Journal of Advanced Pharmaceutical Technology & Research, 2022
pelB has been known as a successful signal peptide to translocate the protein target extracellularly in the Escherichia coli system. However, in our previous study, the yield of MPT64 protein extracellular recovery was still low and plenty of this ...
Sri Agung Fitri Kusuma, Toto Subroto, Ida Parwati, Yaya Rukayadi, Muhammad Fadhlillah, Ruth Michellee Pardede, Alif Virisy Berlian, Gina Sabila   +7 more
doaj   +1 more source

Real-Time Amperometric Recording of Extracellular H2O2 in the Brain of Immunocompromised Mice: An In Vitro, Ex Vivo and In Vivo Characterisation Study

Sensors, 2017
We detail an extensive characterisation study on a previously described dual amperometric H2O2 biosensor consisting of H2O2 detection (blank) and degradation (catalase) electrodes.
Caroline H. Reid, Niall J. Finnerty
doaj   +1 more source

Thiol Modifications in the Extracellular Space—Key Proteins in Inflammation and Viral Infection

Frontiers in Immunology, 2022
Posttranslational modifications (PTMs) allow to control molecular and cellular functions in response to specific signals and changes in the microenvironment of cells. They regulate structure, localization, stability, and function of proteins in a spatial
Kathrin A. Brücksken, Paola Loreto Palacio, Eva-Maria Hanschmann   +2 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

eDNA State and Medium Affect DNA Degradation Patterns in Seminatural Systems of Southern African Waterholes

Environmental DNA
Environmental DNA (eDNA) has evolved into a valuable asset of the ecologists' toolkit, enabling time‐ and cost‐efficient biodiversity assessments in a wide variety of ecosystems.
Irmgard Sedlmayr, Tamara Schenekar
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source