Results 251 to 260 of about 481,952 (302)

Raman Microscopy at the Organic–Inorganic Interfaces in Human Calcified Aortic Valves Shows the Co‐Existence of Whitlockite Crystals and Carbonated Hydroxyapatite‐Mineralized Collagen Fibrils

Advanced Functional Materials, EarlyView.
This study advances our understanding of aortic valve stenosis by capturing spatially resolved chemical and structural changes at the nanoscale. The findings highlight the potential of combined Raman and electron microscopy for understanding calcification mechanisms across diverse tissue types.
Robin H. M. Van der Meijden, Carolien T. A Kuster, Amber van Broekhoven, Raphaela Allgayer, Luco Rutten, Rona Roverts, Marta Cerruti, Elena Macías‐Sánchez, Jan Hein Cornel, Salloua el Messaoudi, Anat Akiva, Nico Sommerdijk   +11 more
wiley   +1 more source

Diverse temporal and spatial mechanisms work, partially through Stanniocalcin-1, V-ATPase and senescence, to activate the extracellular ATP-mediated drug resistance in human cancer cells. [PDF]

Front Oncol
Zhang H, Song J, Ward R, Han Y, Hunt A, Shriwas P, Steed A, Edwards C, Cao Y, Co M, Chen X.   +10 more
europepmc   +1 more source

P2 X 7 receptor is a critical regulator of extracellular ATP-induced profibrotic genes expression in rat kidney: implication of transforming growth factor-β/Smad signaling pathway. [PDF]

Purinergic Signal
Mounieb F, Abdel-Sattar SA, Balah A, Akool ES.   +3 more
europepmc   +1 more source

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Extracellular ATP, P2 receptors, and inflammation

Drug Development Research, 2003
AbstractOver the past few years, P2 receptors have emerged as new potential players in the early phases of inflammation in their function of chemotactic receptors, triggers of proinflammatory cytokine release, and cytotoxic molecules. However, more recent data suggest that the role of P2 receptors in immunity is much more widespread and touches the ...
Di Virgilio F., Ferrari D., Idzko M., Panther E., Norgauer J., La Sala A., Girolomoni G.   +6 more
openaire   +3 more sources

Extracellular ATP signaling and clinical relevance

Clinical Immunology, 2018
Since purinergic signaling was discovered in the early 1970s, it has been shown that extracellular nucleotides, and their derivative nucleosides, are released in a regulated or unregulated manner by cells in various challenging settings and then bind defined purinergic receptors to activate intricate signaling networks.
Lei Dou, Yi-Fa Chen, Peter J. Cowan, Xiao-Ping Chen   +3 more
openaire   +2 more sources

W1551 Extracellular ATP Synthase Generates Extracellular ATP, Regulating Bicarbonate Secretion in Rat Duodenum

Gastroenterology, 2009
The pH of the alkaline microclimate overlying the duodenal enterocyte brush border is regulated by an ecto-purinergic signaling system consisting of intestinal alkaline phosphatase (IAP), extracellular ATP and P2Y receptors. This system regulates the rate of duodenal bicarbonate secretion (DBS).
Chikako Watanabe, Yasutada Akiba, Takanari Nakano, Paul H. Guth, Eli Engel, Seema Khurana, Jonathan D. Kaunitz   +6 more
openaire   +1 more source

Assessment of Extracellular ATP Concentrations

2009
Most cells release ATP to the extracellular milieu. Extracellular ATP plays important signaling roles by activating a score of broadly distributed cell surface purinergic receptors (purinoceptors). Biological responses regulated by purinergic receptors include neurotransmission, smooth muscle relaxation and contraction, epithelial cell ion transport ...
Lucia, Seminario-Vidal, Eduardo R, Lazarowski, Seiko F, Okada   +2 more
openaire   +2 more sources

Abstract 1703: Extracellular ATP mediated intracellular ATP increase: Evidence for transport of extracellular ATP into cancer cells.

Cancer Research, 2013
Abstract ATP as a most common cofactor of enzymatic reactions and a universal source of bioenergy transfer plays central metabolic and signal transduction roles in normal and cancer cells. Almost all cancer cells switch from the highly efficient mitochondrial oxidative phosphorylation to low efficiency glycolysis for ATP synthesis, a ...
Yanrong Qian, Yi Liu, Xuan Wang, Xiaozhuo Chen   +3 more
openaire   +1 more source

Effects of Extracellular ATP on Mononuclear Phagocytes

Annals of the New York Academy of Sciences, 1990
Vedi ...
Steinberg TH, Buisman HP, Greenberg S, DI VIRGILIO, Francesco, Silverstein SC   +4 more
openaire   +2 more sources

Extracellular ATP regulates glomerular endothelial cell function

Journal of Autonomic Pharmacology, 1996
1. Glomerular endothelial cells form the inner part of the filtration barrier and are involved in pathophysiological processes in the glomerulum. New techniques for culturing glomerular endothelial cells have been established recently. The effect of extracellular ATP on membrane voltage and intracellular calcium activity was examined in bovine ...
Pavenstädt, Hermann, Henger, Anna, Briner, Verena, Greger, Rainer F, Schollmeyer, Peter J.   +4 more
openaire   +3 more sources